Andreea- Iulia Dobrescu, Lavinia Ardelean, Clara Matei, Mircea Tampa, Maria Puiu, Stefan MihAicusa Polysomnography Test and Sleep Disordered Breathing in Prader-Willi Syndrome
Polysomnography is a new and innovative test used for the diagnosis of sleep disorders. It offers the possibility to identify and to early treat important diseases which can lead sudden to death in children and adults too. The portable monitor simplifies the procedure and it permits to monitor the patients at home. Obesity is the most powerful and the only reversible risk factor for obstructive sleep apnea. This condition is one of the most serious problem of the 21st century. It can appear like common obesity caused by an increased food intake and it is also part of some rare genetic syndromes. Prader Willi Syndrome is a genetic disorder caused by an abnormality on the 15th chromosome. It is the most common known genetic cause of life-threatening obesity in children. The study aims to describe sleep disorders in patients diagnosticated with this genetical syndrome. The evaluated patients associated a characteristically phenotype for Prader Willi Syndrome with unrest sleep and they had no treatment before. A high number of obstructive sleep apneas and rapid eye movement sleep alteration was registered. Breath and cardio-vascular pathological changes were also identified. Large fluctuations in heart rate and relatively long duration of low oxygen saturation was threatening patients life and nasal continuous airway pressure was needed in order to reverse respiratory and cardiovascular symptoms. Keywords: polysomnography, obstructive sleep apnea, sleep disorders, Prader Willi Syndrome
Cosmin Sinescu, Laura Cristina Rusu, Eliza Seche, Paul Cornel Freiman, Emanuela Lidia Craciunescu, Meda Lavinia Negrutiu An Imagistic Approach on Resin Composite Class I Dental Fillings with Improved Adhesive with Ferric Nanoparticles
Dental composite resins already have a history and a vast use in dentistry. In vivo and in vitro research gave precise directions and indications but the tests are not completely relevant. Different clinical parameters cannot be reproduced by in vivo and in vitro research. The evolution of dental materials leads to the use of nano materials. For the present study, were used human extracted teeth on which were prepared class I cavities. For half of the samples had been used normal adhesive and composite resin and for the second group was used nanomaterials- a ferric nanoparticles modified dental adhesive was used and then filled with the same resin composite material. The interfaces generated by hard dental tissue and classical adhesive and adhesive made from nano-particles were investigated through micro-CT imagistic investigation method. With the software VGStudio MAX the 3D reconstruction of the constituents were made. Micro-CT using the synchrotron technology and 3D reconstruction offers important details and of high quality of investigated area. All the samples were imagistic investigated through, X-ray, SEM and EDAX technologies. Each investigation method spotted the defects of the investigated area according to its limitation. Keywords: composite resin, dental adhesive, feeric nanoparticles, micro-CT, X-ray, SEM, EDAX
SUNITA ANDREEA MOGA, NICOLAE GOGA, SVETLANA BAOUKINA, CATINCA SECUIANU, ANTON HADAR Simulations on DPD Thermostat and Standard MD for Different Systems
This article presents a benchmark between Dissipative Particle Dynamics (DPD) thermostat and Standard Molecular Dynamics (MD) simulations for three different systems: a water cube, a small dipalmitoylphosphatidylcholine (DPPC) bilayer in water, and a large DPPC bilayer in water. The DPPC phospholipids’ molecule consists of a hydrophilic head and two hydrophobic tails. The molecular dynamics simulations results for the three above systems as function of number of cores are shown. Keywords: molecular dynamics, thermostats, friction
TOM SAVU, BOGDAN FELICIAN ABAZA, PAULINA SPANU Artificial Intelligence based System for the Real-time Control of Polymerization Processes
The paper describes the components of an artificial intelligence based system intended to control the manufacturing processes of composite materials with polymeric matrix. Based on previous results in which neural networks were trained initially with simulated data and then continued to acquire experimental values over Internet for refining their knowledge, the system includes updated state-of-the-art data acquisition components, improved statistical data processing capabilities and the ability of real-time controlling the manufacturing equipment. Keywords: composite materials, polymeric matrix, artificial intelligence
ADELINA DAVID, MIRCEA TEODORESCU, PAUL O. STANESCU, STEFANIA STOLERIU Novel Poly(ethylene glycol) Composite Hydrogels with Hydrophilic Bentonite Nanoclay as the Filler
Novel composite poly(ethylene glycol) hydrogels with hydrophilic bentonite as the filler were synthesized by the polyaddition reaction between diepoxy-terminated PEG of 2000 Da, 6000 Da and 10000 Da molecular weights and ethylenediamine in aqueous solution at 60°C, in the presence of the clay. The hydrogels prepared were tested from the point of view of their swelling behaviour and mechanical properties. The results showed that the clay practically did not affect both the water absorption by the crosslinked polymer and the storage modulus of the hydrogels. This seems to indicate that the interactions between the PEG chains and bentonite were very small or absent within the hydrogels in the presence of water, although they occurred in dry state, as proven by FTIR and XRD measurements upon xerogels. Keywords: hydrogels; poly(ethylene glycol); bentonite; composite
Catalin Zaharia, Paul Octavian Stanescu Bacterial Cellulose Grafted with Acidic Groups for Biomedical Applications
The paper focuses on the synthesis and evaluation of biomineralization potential of composite materials based on bacterial cellulose and synthetic acrylic polymers with negative groups attached. The composite materials were obtained by grafting the monomers carrying negative groups onto the surface of bacterial cellulose. These grafted membranes were then subject to mineralization assay according to T. Kokubo protocol. Cytototoxicity test have shown that this kind of composites did not show a significant in vitro cytotoxicity and could be used for developing biomedical applications. Keywords: bacterial cellulose, acrylic monomers, biomineralization, hydroxyapatite
SORINA ALEXANDRA GAREA, ADI GHEBAUR, EUGENIU VASILE Drug Delivery Systems based on Poly(vinyl alcohol)-layered Silicates Hybrid Films
New systems based on poly(vinyl alcohol), unmodified and modified layered silicates were designed for drug delivery applications. Unmodified and modified montmorillonite with different agents were used as inorganic component in the hybrid structures. The thermogravimetric analysis (TGA), X-Ray Photoelectron Spectroscopy (XPS), X-Ray Diffractions (XRD) and FTIR analysis were useful to characterize the hybrid materials. The modifier agent type used for montmorillonite treatment and the presence of montmorillonite in the polymeric films strongly influence the hybrid materials properties and drug release profile. Keywords: poly(vinyl alcohol), hybrid materials, montmorillonite, 5-fluorouracil, UV-Vis, X-Ray Photoelectron Spectroscopy
Alina Raditoiu, Viorica Amariutei, Valentin Raditoiu*, Luminita Eugenia Wagner, Raluca Augusta Gabor, Marius Ghiurea, Catalin Ilie Spataru Protein Textile Fibers Coated with Silica – azo Disperse Dyes Hybrid Film-forming Materials
The paper presents experimental data regarding morphology and hydrophobic character of some film building silica hybrids containing disperse dyes embedded or covalently linked into the inorganic network, used as coating materials for protein textile fibers. Thermo-mechanical properties of the textiles coated with the colored film forming materials are studied in relation with the coating materials composition. Keywords: thermo-mechanical properties, hydrophobic character, silica hybrids, disperse dyes,protein fibers
Daniela Teodorescu, Camelia Hodosan, Lucica Nistor, Gheorghe Hubca Researches on Multilayer Films with Barrier and Antimicrobial Properties
This paper has had as purpose rendering of some researches related to extrusion velocities while obtaining multilayer films with superior barrier and antimicrobial properties, of five layers of polymer with ionomer content, including antimicrobial. An installation comprising five extruders has been used for trials and the working velocities have been determined for each layer, as well as the shear stress at the wall of the nozzle. The results thus obtained made possible to settle the optimum parameters for the extrusion process able to ensure a stable flow of the molten polymer, which resulted in a uniform multilayer, faultless structural film, with superior barrier and antimicrobial effects. Keywords: polyethylene, EVA, EVOH, extrusion, co-extrusion, multilayer film
STEFAN ROBU, RAISA ZHITARU, ECATERINA VIERU, VITALIE FILIP, NATALIA PALISTRANT, ALEXEI MESHALKIN, PAUL GHIOCA, LORENA IANCU Microhardness Investigation of Styrene-butyl Methacrylate-methacrylic Acid Copolymer and its Analogous Grafted with Ampicillin
This paper presents the study of Vickers microhardness performed on a styrene-butyl methacrylate- methylacrylic acid copolymer and the analogous obtained by grafting with ampicilline. The creep properties and the glass transition temperature of the copolymers were investigated. Keywords: microhardness, styrene-butyl methacrylate-methylacrylic acid copolymer, creep,Tg