Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate

Marin, Aurel; Marin, Maria Alina; Ene, Ioan; Poenaru, Marioara

Aurel Marin, Maria Alina Marin, Ioan Ene, Marioara Poenaru

Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate

Abstract:
The current study was proposed in order to obtain, to characterize by usually physico-chemical methods and to assess in vitro, the potential cytotoxic effect of polyurethane microstructures loaded with epigallocatechin gallate (PU_MS) on human pharyngeal carcinoma cells (Detroit 562) and squamous cell carcinoma (SCC-4). The results showed that polyurethane microstructures obtained are stable and have dimensions that make them biocompatible with the biological environment. The cytotoxicity of test samples is dependent on concentration and 72 hours after stimulation at the highest concentration tested the viability of tumor cells was below 50%, the decrease being much more pronounced in the case of squamous cell carcinoma. The novel nanostructures loaded with epigallocatechin gallate induced an augmented cytotoxic effect, suggesting that this drug carriers are suitable to enhance the antitumor effect of epigallocatechin gallate.

Keywords:
drug transporter; polyurethane strucrures; thermal degradation; cell viability; carcinoma cells

Issue: 2021 Volume 58, Issue 1

Pages: 210-217

Publication date: 2021/4/5

https://doi.org/10.37358/MP.21.1.5460

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MARIN, A., MARIN, M.A., ENE, I., POENARU, M., Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate, Mater. Plast., 58(1), 2021, 210-217. https://doi.org/10.37358/MP.21.1.5460

Vancouver
Marin A, Marin MA, Ene I, Poenaru M. Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate. Mater. Plast.[internet]. 2021 Jan;58(1):210-217. Available from: https://doi.org/10.37358/MP.21.1.5460

APA 6th edition
Marin, A., Marin, M.A., Ene, I. & Poenaru, M. (2021). Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate. Materiale Plastice, 58(1), 210-217. https://doi.org/10.37358/MP.21.1.5460

Harvard
Marin, A., Marin, M.A., Ene, I., Poenaru, M. (2021). 'Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate', Materiale Plastice, 58(1), pp. 210-217. https://doi.org/10.37358/MP.21.1.5460

IEEE
A. Marin, M.A. Marin, I. Ene, M. Poenaru, "Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate". Materiale Plastice, vol. 58, no. 1, pp. 210-217, 2021. [online]. https://doi.org/10.37358/MP.21.1.5460

Text
Aurel Marin, Maria Alina Marin, Ioan Ene, Marioara Poenaru,
Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate,
Materiale Plastice,
Volume 58, Issue 1,
2021,
Pages 210-217,
ISSN 2668-8220,
https://doi.org/10.37358/MP.21.1.5460.
(https://revmaterialeplastice.ro/Articles.asp?ID=5460)
Keywords: drug transporter; polyurethane strucrures; thermal degradation; cell viability; carcinoma cells

RIS
TY - JOUR
T1 - Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate
A1 - Marin, Aurel
A2 - Marin, Maria Alina
A3 - Ene, Ioan
A4 - Poenaru, Marioara
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2021
VL - 58
IS - 1
SP - 210
EP - 217
UR - https://doi.org/10.37358/MP.21.1.5460
KW - drug transporter
KW - polyurethane strucrures
KW - thermal degradation
KW - cell viability
KW - carcinoma cells
ER -

BibTex
@article{MatPlast2021P210,
author = {Marin Aurel and Marin Maria Alina and Ene Ioan and Poenaru Marioara},
title = {Polyurethane Structures Used as a Drug Carrier for Epigallocatechin Gallate},
journal = {Materiale Plastice},
volume = {58},
number = {1},
pages = {210-217},
year = {2021},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.21.1.5460},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5460}
}

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