Abstract
During endodontic therapy, an important effect of the reparative materials used is to induce periapical recovery and stimulation of osteogenesis. The study aimed to assess the dynamics of alkaline phosphatase levels measured at different time intervals and was conducted by implanting three biomaterials in the rabbit subcutaneous connective tissue, next to the bone. The biomaterials used were: MTA (Mineral Trioxide Aggregate, Dentsply, Tulsa Dental, U.S.A.), Sealapex (Kerr, Switzerland), and DiaRoot Bioaggregate (Inovatore BioCaramixInc, Vancouver, BC, Canada). This study was focused on a quantitative analysis, based on biochemical examination. Keywords: alkaline phosphatase, osteogenesis, biomaterials, endodontic treatment, stomatognathic system homeostatis