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Open Access Research Article

Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine

Oana Ionescu (Filip), Maria Viorica Ciocilteu, Costel Valentin Manda, Ionela Andreea Neacsu, Anton Ficai, Emilia Amzoiu, Adina Turcu Stiolica, Octavian Croitoru, Johny Neamtu
Published 30 Sep 2019
Pages 534–537

Abstract

The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers (collagen) and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer. Regardless of the chosen method, the percentage of the encapsulated drug was found to be quite high: 15.92% in the Coll-HA-Genta material and 19.59% respectively in the PLGA-Genta biocomposite. The therapeutic value of gentamicin was improved by encapsulating it in delivery systems, contributing to sustained release for a long time (about 30 days).

Keywords: collagen-hidroxiapatite; PLGA-gentamicin; biocomposites; biodegradability

How to Cite this Article

(Filip), O., Ciocilteu, M., Manda, C., Neacsu, I., Ficai, A., Amzoiu, E., Stiolica, A., Croitoru, O., & Neamtu, J. (2019). Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine. Materiale Plastice, 56(3), 534–537. https://doi.org/10.37358/MP.19.3.5224
(Filip) O, Ciocilteu M, Manda C, Neacsu I, Ficai A, Amzoiu E, Stiolica A, Croitoru O, Neamtu J. Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine. Materiale Plastice. 2019;56(3):534–537. doi: 10.37358/MP.19.3.5224
O. (Filip), M. Ciocilteu, C. Manda, I. Neacsu, A. Ficai, E. Amzoiu, A. Stiolica, O. Croitoru, and J. Neamtu, "Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine,” Materiale Plastice, vol. 56, no. 3, pp. 534–537, 2019. doi: 10.37358/MP.19.3.5224
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