Abstract
The aim of our study was to obtain cellulose acetate composites based on hydroxyapatite and nystatin with increased local therapeutic effect in the therapy of candidiasis. The porous composites were obtained by phase inversion method. Antifungal susceptibility of the samples was investigated by the Kirby Bauer Disk Diffusion test. The method has demonstrated an antifungal effect of the samples against Candida albicans as well as the fact that the polyene antibiotic nystatin might be an optimal choice as active agent incorporated in a composite. Also we have studied the swelling and the degradation of the membranes. These measurements help us better understand the water and PBS absorption capacity of the polymer matrix. Keywords: Composite, cellulose acetate, hydroxyapatite, nystatin, antifungal activity