Abstract
Combining polimers with polyphenols such as gallic acid opens up new directions in healthcare system. By encapsulating secondary metabollites within PLGA nanoparticles, we tried to enhance their stability, solubility, and obtain a targeted delivery system. In this study, we synthesized a PLGA-gallic acid sustained release system, using the solvent evaporation method. This approach improved the therapeutic efficacy of gallic acid. The numerical distribution showed that most PLGA-GA nanoparticles have a size of 10 nm. Through the method of solvent evaporation, an incorporation efficiency of 49% was obtained.
Keywords: PLGA; gallic acid; nanocomposite material; solvent evaporation method