Abstract
New systems based on poly(vinyl alcohol), unmodified and modified layered silicates were designed for drug delivery applications. Unmodified and modified montmorillonite with different agents were used as inorganic component in the hybrid structures. The thermogravimetric analysis (TGA), X-Ray Photoelectron Spectroscopy (XPS), X-Ray Diffractions (XRD) and FTIR analysis were useful to characterize the hybrid materials. The modifier agent type used for montmorillonite treatment and the presence of montmorillonite in the polymeric films strongly influence the hybrid materials properties and drug release profile. Keywords: poly(vinyl alcohol), hybrid materials, montmorillonite, 5-fluorouracil, UV-Vis, X-Ray Photoelectron Spectroscopy