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Open Access Research Article

Liposome Loaded Chitosan Hydrogels, a Promising Way to Reduce the Burst Effect in Drug Release. A comparativ analysis

VLADIMIR ALEXANDRU PAUN, MARCEL POPA, JACQUES DESBRIERES, CATALINA ANISOARA PEPTU, STELIAN VALENTIN DRAGAN, GEORGETA ZEGAN, GABRIELA CIOCA
DOI Not yet assigned
Published 30 Dec 2016
Pages 590–593

Abstract

In order to analyze the effect induced by encapsulating the drug in liposomes, comparative studies were performed for control hydrogels and complex systems (the same hydrogels containing liposomes). The results showed that the use of liposomes entrapped within chitosan hydrogels allows a strong decrease of burst effect and, moreover, the mechanism of drug release is a complex Fickian diffusion, consisting of drug diffusion through the swollen hydrogel and/or water filled pores, being continuously fed by calcein loaded in liposomes.

Keywords: liposome; chitosan; drug release; Fickian diffusion

How to Cite this Article

PAUN, V., POPA, M., DESBRIERES, J., PEPTU, C., DRAGAN, S., ZEGAN, G., & CIOCA, G. (2016). Liposome Loaded Chitosan Hydrogels, a Promising Way to Reduce the Burst Effect in Drug Release. A comparativ analysis. Materiale Plastice, 53(4), 590–593.
PAUN V, POPA M, DESBRIERES J, PEPTU C, DRAGAN S, ZEGAN G, CIOCA G. Liposome Loaded Chitosan Hydrogels, a Promising Way to Reduce the Burst Effect in Drug Release. A comparativ analysis. Materiale Plastice. 2016;53(4):590–593.
V. PAUN, M. POPA, J. DESBRIERES, C. PEPTU, S. DRAGAN, G. ZEGAN, and G. CIOCA, "Liposome Loaded Chitosan Hydrogels, a Promising Way to Reduce the Burst Effect in Drug Release. A comparativ analysis,” Materiale Plastice, vol. 53, no. 4, pp. 590–593, 2016.
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