Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications

POENARIU, BEATRICE; AMZOIU, DENISA-CONSTANTINA; CIOCILTEU, MARIA; ENE, VLADIMIR; CIULU-COSTINESCU, FELICIA; NICOLICESCU, CLAUDIU; COSTACHI, ALEXANDRA; CHIRIGIU, LIVIU; POPESCU, MARIANA; NICOLAESCU, OANA

doi:10.37358/MP.24.4.5740

Open Access Research Article

Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications

BEATRICE ANNE-MARIE POENARIU, DENISA-CONSTANTINA AMZOIU, MARIA VIORICA CIOCILTEU, VLADIMIR LUCIAN ENE, FELICIA CIULU-COSTINESCU, CLAUDIU NICOLICESCU, ALEXANDRA COSTACHI, LIVIU CHIRIGIU, MARIANA POPESCU, OANA ELENA NICOLAESCU

DOI 10.37358/MP.24.4.5740

Published 09 Jan 2025

Issue Vol. 61, No. 4

Pages 30–40

Abstract

A new bicomponent hybrid material was obtained by encapsulating quercetin in PLGA using solvent evaporation method. The morphological aspects of the samples were established by scanning electron microscopy (SEM). Particle size distribution was determined by dynamic light scattering (DLS), numerical distribution showing that the particles are micrometric, with two granulometric intervals: [385-479] nm and [662-918] nm. Morphology was typical for PLGA, spherical one; the obtained particles are porous with micrometric pores. Zeta potential (ZP, -4.84mV) showed that the particles have electronegative surface charge. The loading efficiency was determined spectrophotometric and it was 18.3% in the mentioned synthesis conditions.

Keywords: PLGA-Quercetin; solvent evaporation; hybrid material

How to Cite this Article

POENARIU, B., AMZOIU, D., CIOCILTEU, M., ENE, V., CIULU-COSTINESCU, F., NICOLICESCU, C., COSTACHI, A., CHIRIGIU, L., POPESCU, M., & NICOLAESCU, O. (2025). Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications. Materiale Plastice, 61(4), 30–40. https://doi.org/10.37358/MP.24.4.5740

POENARIU B, AMZOIU D, CIOCILTEU M, ENE V, CIULU-COSTINESCU F, NICOLICESCU C, COSTACHI A, CHIRIGIU L, POPESCU M, NICOLAESCU O. Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications. Materiale Plastice. 2025;61(4):30–40. doi: 10.37358/MP.24.4.5740

B. POENARIU, D. AMZOIU, M. CIOCILTEU, V. ENE, F. CIULU-COSTINESCU, C. NICOLICESCU, A. COSTACHI, L. CHIRIGIU, M. POPESCU, and O. NICOLAESCU, "Formulation and Characterization of PLGA-quercetin Hybrid Material with Pharmaceutical Applications,” Materiale Plastice, vol. 61, no. 4, pp. 30–40, 2025. doi: 10.37358/MP.24.4.5740

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