Abstract
In this work, we focused on the potential of biogenous mineral from Cuttlefish bone for inducing biomimetic mineralization with further biomedical applications. We demonstrate the formation of strong and flexible hydrogels via physical immobilization of cuttlefish bone powder in the presence of bovine gelatin and alginate. The properties of hydrogels loaded with biogenous mineral, with a commercial bone substitute, with commercial nano-hydroxyapatite and in situ generated hydroxyapatite. In vitro cell adhesion tests demonstrated that the new developed hydrogels showed a promising cell adhesion.
Keywords: cuttlefish bone; mineral phase; gelatin-alginate hydrogels; biocompatibility