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Open Access Research Article

Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application

Adi Ghebaur, Sorina Alexandra Garea, Sergiu Cecoltan, Horia Iovu
Published 30 Mar 2017
Pages 8–13

Abstract

The influence of aluminosilicates on the structure and drug release profiles of polyvinyl alcohol (PVA) – halloysite (HNT) hydrogels containing acetylsalicylic acid (ASA) as a model drug was monitored. The hydrogels were synthesized using a three cycle freeze – thawing procedure and were characterized by FTIR, XRD and SEM. The swelling degree and cytotoxicity were also determined. All hydrogels properties were influenced by HNT concentration from the polymer matrix. The release of ASA, from PVA – HNT hydrogels was monitored in the gastrointestinal tract conditions.

Keywords: freeze-thawing; halloysite; acetylsalicylic acid; polyvinyl alcohol

How to Cite this Article

Ghebaur, A., Garea, S., Cecoltan, S., & Iovu, H. (2017). Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application. Materiale Plastice, 54(1), 8–13. https://doi.org/10.37358/MP.17.1.4774
Ghebaur A, Garea S, Cecoltan S, Iovu H. Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application. Materiale Plastice. 2017;54(1):8–13. doi: 10.37358/MP.17.1.4774
A. Ghebaur, S. Garea, S. Cecoltan, and H. Iovu, "Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application,” Materiale Plastice, vol. 54, no. 1, pp. 8–13, 2017. doi: 10.37358/MP.17.1.4774
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