Abstract
Extracellular matrix biocomposites based on poly(ester urethane), and hydrolyzed collagen, elastin, chondroitin sulfate and hyaluronic acid have been prepared. Different surface morphologies for each of the test matrices were revealed by Environmental Scanning Electron Microscope (ESEM). The biological material used is a very wide spread aggressive fungal species in all media for life, Mucor mucedo. Evaluation of the biologically active potential of these biocomposites against Mucor mucedo has been done through inoculation onto Sabouraud –agar nutrient medium. Fungal growth was monitored over 60 days.Visual observations of the fungal growth show that Mucor mucedo was aggressive and caused rapid grow after 72 h of inoculation onto Sabouraud-agar nutrient medium, but the biopolyurethane composites samples relatively to the fungal attack particularly showed a different relationship. Keywords: biomaterials; composites; polyurethanes; Mucor mucedo; extracellular matrix