Abstract
The studies were concerned on the releasing of nystatin from polyurethane urea (PUU) microporous membrane at different pH values at room temperature. The whole ATR-FTIR spectrum of PUU-nystatin is shifted to smaller wave numbers compared to control PUU which indicates the increasing of structurated degree of PUU-nystatin. The stress-strain curves are sustained by the ATR-FTIR results demonstrating the structurating effects of a polar bioactive nystatin materialized through an increasing of the initial modulus. The nystatin delivery in watery solution has a strong reaction to pH. At pH 3, in the first 170 minutes, the nystatin is released in proportion of 38% whereafter drug release is approximately constant in time. Key words: polyurethane urea, nystatin, release