Abstract
This work presents a study on the possibility of hydroxyapatite thin layers deposition on porous polyurethane support using biomimetic method, and pyridoxine (vitamin B6) incorporation in this layer. To achieve the formation of hydroxyapatite deposition on the surface of polyurethane and to incorporate the pyridoxine in the apatite layer, two types of biomimetic solutions, i.e. a supersaturated calcification solution (denoted SCS) and a modified SCS solution (denoted M-SCS) were used. The M-SCS solution was prepared by adding in the original SCS solution appropriate quantities of pyridoxine. The hydroxyapatite deposits are investigated by scanning electron microscopy (SEM) and Fourier-transform infrared transmission spectroscopy (FT-IR). The results obtained from SEM images and FT-IR spectra have shown that porous polyurethane/hydroxyapatite scaffolds with an interconnected network were produced, and pyridoxine is incorporated in the apatite layer. Keywords: Hydroxyapatite, polyurethane, pyridoxine, scaffold