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Materiale Plastice
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https://doi.org/10.37358/Mat.Plast.1964

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Materiale Plastice (Mater. Plast.), Year 2022, Volume 59, Issue 2, 183-193

https://doi.org/10.37358/MP.22.2.5597

Mircea Popitiu, Sorin Barac, Florin Borcan, Giacomo Clerici, Andreea Rata

Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept


Abstract:
Atherosclerosis can affect the blood vessels in any region of the body and the stenosis (narrowing) can be located on an artery that vascularize important organs, such as the brain, abdominal organs or limbs. The endovascular surgery is a modern approach to vascular pathology through minimally invasive techniques (puncture, minimally vascular approach) and it represents an enrichment of the arsenal of surgical techniques and brings considerable improvements in post-operative and long-term outcomes The use of polymer drug-coating balloons is an attractive alternative because they can offer the promise of an improved patency compared to the simple balloons and a reduction in the need for stents. The aims of this study were to describe the polymer materials and to compare the medical endpoints obtained in angiosome-targeted infrapopliteal angioplasty using a simple balloon with two layers, based on polyethylene, and respectively a drug-coated balloon that contains a multiblock copolymer from polyethylene, poly(cylohexylethylene), polyisoprene and poly(1,3-butadiene) covered by Paclitaxel. The balloons were characterized by differential scanning calorimetry, stress-strain and puncture tests in order to describe their physical and mechanical characteristics. On the other hand, 51 patients with critical limb ischemia were treated with different balloon angioplasty and they were monitored for 12 months after the intervention; the following parameters have been evaluated: diabetes, hypertension, renal insufficiency, hemodialysis, stroke, dyslipidemia, heart disease, heart failure, body mass index, number of angiosomes, creatinine, and wound healing, leg salvage and amputation-free survival at 1, 2, 3, 6, 9, 12 months. Significant associations were found in the case of anterior-tibial-artery and posterior-tibial-artery angioplasy and the age, hypertension and renal insufficiency. On the other hand, the results indicate that the drug deposition on the surface of the balloons lead to improved values for the observed medical endpoints. In conclusion, this study reveals that angiosome-based infrapopliteal angioplasty with drug-coated balloons can be associated with better wound healing and leg salvage.


Keywords:
angiosomes concept; DSC; percutaneous transluminal angioplasty; puncture test; stress-strain curve

Issue: 2022 Volume 59, Issue 2
Pages: 183-193
Publication date: 2022/7/1
https://doi.org/10.37358/MP.22.2.5597
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
POPITIU, M., BARAC, S., BORCAN, F., CLERICI, G., RATA, A., Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept, Mater. Plast., 59(2), 2022, 183-193. https://doi.org/10.37358/MP.22.2.5597

Vancouver
Popitiu M, Barac S, Borcan F, Clerici G, Rata A. Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept. Mater. Plast.[internet]. 2022 Apr;59(2):183-193. Available from: https://doi.org/10.37358/MP.22.2.5597


APA 6th edition
Popitiu, M., Barac, S., Borcan, F., Clerici, G. & Rata, A. (2022). Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept. Materiale Plastice, 59(2), 183-193. https://doi.org/10.37358/MP.22.2.5597


Harvard
Popitiu, M., Barac, S., Borcan, F., Clerici, G., Rata, A. (2022). 'Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept', Materiale Plastice, 59(2), pp. 183-193. https://doi.org/10.37358/MP.22.2.5597


IEEE
M. Popitiu, S. Barac, F. Borcan, G. Clerici, A. Rata, "Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept". Materiale Plastice, vol. 59, no. 2, pp. 183-193, 2022. [online]. https://doi.org/10.37358/MP.22.2.5597


Text
Mircea Popitiu, Sorin Barac, Florin Borcan, Giacomo Clerici, Andreea Rata,
Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept,
Materiale Plastice,
Volume 59, Issue 2,
2022,
Pages 183-193,
ISSN 2668-8220,
https://doi.org/10.37358/MP.22.2.5597.
(https://revmaterialeplastice.ro/Articles.asp?ID=5597)
Keywords: angiosomes concept; DSC; percutaneous transluminal angioplasty; puncture test; stress-strain curve


RIS
TY - JOUR
T1 - Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept
A1 - Popitiu, Mircea
A2 - Barac, Sorin
A3 - Borcan, Florin
A4 - Clerici, Giacomo
A5 - Rata, Andreea
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2022
VL - 59
IS - 2
SP - 183
EP - 193
UR - https://doi.org/10.37358/MP.22.2.5597
KW - angiosomes concept
KW - DSC
KW - percutaneous transluminal angioplasty
KW - puncture test
KW - stress-strain curve
ER -


BibTex
@article{MatPlast2022P183,
author = {Popitiu Mircea and Barac Sorin and Borcan Florin and Clerici Giacomo and Rata Andreea},
title = {Comparative Investigation on Polymer Drug-coating Balloons Used in Infrapopliteal Angioplasty Based on Angiosomes Concept},
journal = {Materiale Plastice},
volume = {59},
number = {2},
pages = {183-193},
year = {2022},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.22.2.5597},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5597}
}


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