5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects

Iancu, Roxana; Irimiciuc, Stefan Andrei; Agop, Maricel; Frasila, Mihail; Paun, Maria-Alexandra; Paun, Vladimir-Alexandru; Paun, viorel-Puiu; Stratulat, Sorin

Roxana Iancu, Stefan Andrei Irimiciuc, Maricel Agop, Mihail Frasila, Maria-Alexandra Paun, Vladimir-Alexandru Paun,viorel-Puiu Paun, Sorin Stratulat

5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects

Abstract:
A series of four drug release formulations based on 5-fluorouracil encapsulated into a chitosan-based matrix were prepared by in situ hydrogelation with 3,7-dimethyl-2,6-octadienal. The formulations were investigated from structural and morphological aspects by FTIR spectroscopy, polarized light microscopy and scanning electron microscopy. It was established that 5-fluorouracil was anchored into the matrix as crystals, whose dimension varied as a function of the crosslinking density. The in vitro drug release simulated into a media mimicking the physiological environment revealed a progressive release of the 5-fluorouracil, in close interdependence with the crosslinking density. In the context of Pharmacokinetics behavioral analysis, a new mathematical procedure for describing drug release dynamics in polymer-drug complex system is proposed. Assuming that the dynamics of polymer-drug system’s structural units take place on continuous and nondifferentiable curves (multifractal curves), we show that in a one-dimensional hydrodynamic formalism of multifractal variables the drug release mechanism (Fickian diffusion, non-Fickian diffusion, etc) are given through synchronous dynamics at a differentiable and non-differentiable scale resolutions. Finally, the model is confirmed by the empirical data.

Keywords:
drug release; dynamics; polymer; non-differentiable scale; multifractal curves

Issue: 2020 Volume 57, Issue 3

Pages: 180-188

Publication date: 2020/9/30

https://doi.org/10.37358/MP.20.3.5392

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IANCU, R., IRIMICIUC, S.A., AGOP, M., FRASILA, M., PAUN, M., PAUN, V., PAUN, V., STRATULAT, S., 5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects, Mater. Plast., 57(3), 2020, 180-188. https://doi.org/10.37358/MP.20.3.5392

Vancouver
Iancu R, Irimiciuc SA, Agop M, Frasila M, Paun M, Paun V, Paun v, Stratulat S. 5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects. Mater. Plast.[internet]. 2020 Jul;57(3):180-188. Available from: https://doi.org/10.37358/MP.20.3.5392

APA 6th edition
Iancu, R., Irimiciuc, S.A., Agop, M., Frasila, M., Paun, M., Paun, V., Paun, v. & Stratulat, S. (2020). 5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects. Materiale Plastice, 57(3), 180-188. https://doi.org/10.37358/MP.20.3.5392

Harvard
Iancu, R., Irimiciuc, S.A., Agop, M., Frasila, M., Paun, M., Paun, V., Paun, v., Stratulat, S. (2020). '5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects', Materiale Plastice, 57(3), pp. 180-188. https://doi.org/10.37358/MP.20.3.5392

IEEE
R. Iancu, S.A. Irimiciuc, M. Agop, M. Frasila, M. Paun, V. Paun, v. Paun, S. Stratulat, "5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects". Materiale Plastice, vol. 57, no. 3, pp. 180-188, 2020. [online]. https://doi.org/10.37358/MP.20.3.5392

Text
Roxana Iancu, Stefan Andrei Irimiciuc, Maricel Agop, Mihail Frasila, Maria-Alexandra Paun, Vladimir-Alexandru Paun,viorel-Puiu Paun, Sorin Stratulat,
5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects,
Materiale Plastice,
Volume 57, Issue 3,
2020,
Pages 180-188,
ISSN 2668-8220,
https://doi.org/10.37358/MP.20.3.5392.
(https://revmaterialeplastice.ro/Articles.asp?ID=5392)
Keywords: drug release; dynamics; polymer; non-differentiable scale; multifractal curves

RIS
TY - JOUR
T1 - 5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects
A1 - Iancu, Roxana
A2 - Irimiciuc, Stefan Andrei
A3 - Agop, Maricel
A4 - Frasila, Mihail
A5 - Paun, Maria-Alexandra
A6 - Paun, Vladimir-Alexandru
A7 - Paun, viorel-Puiu
A8 - Stratulat, Sorin
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2020
VL - 57
IS - 3
SP - 180
EP - 188
UR - https://doi.org/10.37358/MP.20.3.5392
KW - drug release
KW - dynamics
KW - polymer
KW - non-differentiable scale
KW - multifractal curves
ER -

BibTex
@article{MatPlast2020P180,
author = {Iancu Roxana and Irimiciuc Stefan Andrei and Agop Maricel and Frasila Mihail and Paun Maria-Alexandra and Paun Vladimir-Alexandru and Paun viorel-Puiu and Stratulat Sorin},
title = {5-Fluorouracil Release from Chitosan-Based Matrix.Experimental and Theoretical Aspects},
journal = {Materiale Plastice},
volume = {57},
number = {3},
pages = {180-188},
year = {2020},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.20.3.5392},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5392}
}

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