Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

Miricescu, Daniela; Totan, Alexandra; Stanescu, Iulia Ioana; Didilescu, Andreea; Sfeatcu, Ruxandra; Stanescu, Ana Maria Alexandra; Stefani3, Constantin; Greabu, Maria

Daniela Miricescu, Alexandra Totan, Iulia Ioana Stanescu, Andreea Didilescu, Ruxandra Sfeatcu, Ana Maria Alexandra Stanescu, Constantin Stefani3, Maria Greabu

Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats

Abstract:
The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The purpose of our study was to observe the antioxidants effects of entrapped alfa-tocopherol (vitamin E) and lutein in Poly Lactic-CO-Glycolic acid (PLGA) in Wistar rats that received 3 weeks hypercaloric diet. Hepatic and splenic lysates have been used to detect changes in total antioxidant capacity (TAC) and advanced oxidative protein products (AOPP). The AOPP liver levels were statistically decreased in the case of rats groups that received a daily dose of PLGA-lutein or PLGA-vitamin E versus the control group. The AOPP level was decreased but statistically insignificant in Wistar rats spleen who received a daily dose of PLGA-lutein. At hepatic level, TAC was statistically increased in rats groups that received a daily dose of vitamin E or lutein. An increased statistical level of TAC was observed in the spleen cell lysing in Wistar rats who received the daily dose of PLGA-vitamin E. Entrapment of vitamin E and lutein in PLGA structure has diminished the effects of hypercaloric diet and can be considered a attractive and promising approach to enhance the bioavailability and activity of poorly water soluble compounds.

Keywords:
PLGA nanoparticles; vitamin E; lutein; hypercaloric diet

Issue: 2019 Volume 56, Issue 3

Pages: 520-534

Publication date: 2019/9/30

https://doi.org/10.37358/MP.19.3.5221

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIRICESCU, D., TOTAN, A., STANESCU, I.I., DIDILESCU, A., SFEATCU, R., STANESCU, A.M.A., STEFANI3, C., GREABU, M., Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats, Mater. Plast., 56(3), 2019, 520-534. https://doi.org/10.37358/MP.19.3.5221

Vancouver
Miricescu D, Totan A, Stanescu II, Didilescu A, Sfeatcu R, Stanescu AMA, Stefani3 C, Greabu M. Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats. Mater. Plast.[internet]. 2019 Jul;56(3):520-534. Available from: https://doi.org/10.37358/MP.19.3.5221

APA 6th edition
Miricescu, D., Totan, A., Stanescu, I.I., Didilescu, A., Sfeatcu, R., Stanescu, A.M.A., Stefani3, C. & Greabu, M. (2019). Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats. Materiale Plastice, 56(3), 520-534. https://doi.org/10.37358/MP.19.3.5221

Harvard
Miricescu, D., Totan, A., Stanescu, I.I., Didilescu, A., Sfeatcu, R., Stanescu, A.M.A., Stefani3, C., Greabu, M. (2019). 'Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats', Materiale Plastice, 56(3), pp. 520-534. https://doi.org/10.37358/MP.19.3.5221

IEEE
D. Miricescu, A. Totan, I.I. Stanescu, A. Didilescu, R. Sfeatcu, A.M.A. Stanescu, C. Stefani3, M. Greabu, "Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats". Materiale Plastice, vol. 56, no. 3, pp. 520-534, 2019. [online]. https://doi.org/10.37358/MP.19.3.5221

Text
Daniela Miricescu, Alexandra Totan, Iulia Ioana Stanescu, Andreea Didilescu, Ruxandra Sfeatcu, Ana Maria Alexandra Stanescu, Constantin Stefani3, Maria Greabu,
Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats,
Materiale Plastice,
Volume 56, Issue 3,
2019,
Pages 520-534,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.3.5221.
(https://revmaterialeplastice.ro/Articles.asp?ID=5221)
Keywords: PLGA nanoparticles; vitamin E; lutein; hypercaloric diet

RIS
TY - JOUR
T1 - Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats
A1 - Miricescu, Daniela
A2 - Totan, Alexandra
A3 - Stanescu, Iulia Ioana
A4 - Didilescu, Andreea
A5 - Sfeatcu, Ruxandra
A6 - Stanescu, Ana Maria Alexandra
A7 - Stefani3, Constantin
A8 - Greabu, Maria
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 3
SP - 520
EP - 534
UR - https://doi.org/10.37358/MP.19.3.5221
KW - PLGA nanoparticles
KW - vitamin E
KW - lutein
KW - hypercaloric diet
ER -

BibTex
@article{MatPlast2019P520,
author = {Miricescu Daniela and Totan Alexandra and Stanescu Iulia Ioana and Didilescu Andreea and Sfeatcu Ruxandra and Stanescu Ana Maria Alexandra and Stefani3 Constantin and Greabu Maria},
title = {Antioxidant Activity of Entrapped alfa-tocopherol and Lutein in PLGA Nanoparticles in Wistar Rats},
journal = {Materiale Plastice},
volume = {56},
number = {3},
pages = {520-534},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.3.5221},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5221}
}

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