The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet

Miricescu, Daniela; Balan, Daniela Gabriela; Radulescu, Catalina; Radulescu, Radu; Stanescu, Iulia-Ioana; Mohora, Maria; Virgolici, Bogdana; Totan, Alexandra; Greabu, Maria

Daniela Miricescu, Daniela Gabriela Balan, Catalina Radulescu, Radu Radulescu, Iulia-Ioana Stanescu, Maria Mohora, Bogdana Virgolici, Alexandra Totan, Maria Greabu

The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet

Abstract:
PLGA (Poli-lactic-co-glycolic acid) nanoparticles (NPs) are curently used as drug delivery systems for many types of drugs including antioxidants such as vitamin E. The main aim of our study was to test the antioxidant effects of PLGA-vitamin E on Wistar male rats. Two groups of Wistar rats received a hypercaloric diet for 21 days: the first group received besides the hypercaloric diet a daily dose of PLGA loaded with vitamin E and the control group received only the hypercaloric diet. Spleen cellular lysate has been used to detect biomarkers of oxidative stress such as malondialdehyde, glutathione, advanced human oxidative protein and vitamin E. After 3 weeks of treatment, statistical significant changes have been detected between the two groups.

Keywords:
PLGA nanoparticles; spleen; hypercaloric diet

Issue: 2019 Volume 56, Issue 2

Pages: 337-340

Publication date: 2019/6/30

https://doi.org/10.37358/MP.19.2.5182

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIRICESCU, D., BALAN, D.G., RADULESCU, C., RADULESCU, R., STANESCU, I., MOHORA, M., VIRGOLICI, B., TOTAN, A., GREABU, M., The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet, Mater. Plast., 56(2), 2019, 337-340. https://doi.org/10.37358/MP.19.2.5182

Vancouver
Miricescu D, Balan DG, Radulescu C, Radulescu R, Stanescu I, Mohora M, Virgolici B, Totan A, Greabu M. The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet. Mater. Plast.[internet]. 2019 Apr;56(2):337-340. Available from: https://doi.org/10.37358/MP.19.2.5182

APA 6th edition
Miricescu, D., Balan, D.G., Radulescu, C., Radulescu, R., Stanescu, I., Mohora, M.,... Greabu, M. (2019). The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet. Materiale Plastice, 56(2), 337-340. https://doi.org/10.37358/MP.19.2.5182

Harvard
Miricescu, D., Balan, D.G., Radulescu, C., Radulescu, R., Stanescu, I., Mohora, M., Virgolici, B., Totan, A., Greabu, M. (2019). 'The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet', Materiale Plastice, 56(2), pp. 337-340. https://doi.org/10.37358/MP.19.2.5182

IEEE
D. Miricescu, D.G. Balan, C. Radulescu, R. Radulescu, I. Stanescu, M. Mohora, B. Virgolici, A. Totan, M. Greabu, "The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet". Materiale Plastice, vol. 56, no. 2, pp. 337-340, 2019. [online]. https://doi.org/10.37358/MP.19.2.5182

Text
Daniela Miricescu, Daniela Gabriela Balan, Catalina Radulescu, Radu Radulescu, Iulia-Ioana Stanescu, Maria Mohora, Bogdana Virgolici, Alexandra Totan, Maria Greabu,
The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet,
Materiale Plastice,
Volume 56, Issue 2,
2019,
Pages 337-340,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.2.5182.
(https://revmaterialeplastice.ro/Articles.asp?ID=5182)
Keywords: PLGA nanoparticles; spleen; hypercaloric diet

RIS
TY - JOUR
T1 - The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet
A1 - Miricescu, Daniela
A2 - Balan, Daniela Gabriela
A3 - Radulescu, Catalina
A4 - Radulescu, Radu
A5 - Stanescu, Iulia-Ioana
A6 - Mohora, Maria
A7 - Virgolici, Bogdana
A8 - Totan, Alexandra
A9 - Greabu, Maria
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 2
SP - 337
EP - 340
UR - https://doi.org/10.37358/MP.19.2.5182
KW - PLGA nanoparticles
KW - spleen
KW - hypercaloric diet
ER -

BibTex
@article{MatPlast2019P337,
author = {Miricescu Daniela and Balan Daniela Gabriela and Radulescu Catalina and Radulescu Radu and Stanescu Iulia-Ioana and Mohora Maria and Virgolici Bogdana and Totan Alexandra and Greabu Maria},
title = {The Antioxidant Effects of PLGA-based Nanoparticles Loaded with Vitamin E in Rats Treated with Hypercaloric Diet},
journal = {Materiale Plastice},
volume = {56},
number = {2},
pages = {337-340},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.2.5182},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5182}
}

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