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Materiale Plastice
Cite as: Mater. Plast.
https://doi.org/10.37358/Mat.Plast.1964

OSIM Nr. R102356
ISSN Print 0025-5289
ISSN Online 2668-8220
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Materiale Plastice (Mater. Plast.), Year 2019, Volume 56, Issue 1, 285-290

https://doi.org/10.37358/MP.19.1.5167

Bianca Domokos-Hancu, Milena Adina Man, Antigona Carmen Trofor, Carmen Monica Pop, Cristina Maria Gavrilescu, Elena Cojocaru, Andrei Cernomaz, Andrei Lesan, Cristian Boerescu, Roxana-Mihaela Barbu, Florina Popescu

Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres


Abstract:
Given the structural resemblances between glass fiber and asbestos, it is important to understand the mechanisms through which exposure to glass fibers may affect the respiratory system. To study the effect of glass fiber on rat lung through intratracheal exposure, considering the subject’s weight variation, together with haematological parameters, C-reactive protein (CRP), total number of lymphocytes, and IL8 concentration in bronchoalveolar lavage. We performed an intratracheal instillation study on four groups of 8 randomly selected Wistar rats, by administering 3 different doses of glass fiber. The hematocrit value was an indirect indicator of chronic hypoxemia; leukocytes and the C-reactive protein assessed systemic inflammation, and total number of lymphocytes and IL8 concentration in bronchoalveolar lavage fluid determined the lung’s inflammatory response. Weight variation evaluated in all 8 measurements revealed no statistically significant changes (p=0.768). The decrease in mean blood leukocytes was interpreted in relation with the glass fiber dose, with a statistically significant difference between the study groups (p=0.003). Statistically significant differences were found in the CRP values, with dose correlations (p<0.001). The bronchoalveolar lavage fluid showed increased levels of IL-8 (p<0.05), and decrease of lymphocytes (p<0.001) in correlation with the administered glass fiber dose. The inflammatory response following exposure to glass fibers in rats is correlated with administrated glass fiber dose. The alterations described as a result of intratracheal glass fiber instillation could predict the effects which occupational exposure to glass fiber may produce in humans.


Keywords:
glass fiber; intratracheal instillation; animal models; occupational exposure

Issue: 2019 Volume 56, Issue 1
Pages: 285-290
Publication date: 2019/3/30
https://doi.org/10.37358/MP.19.1.5167
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
DOMOKOS-HANCU, B., MAN, M.A., TROFOR, A.C., POP, C.M., GAVRILESCU, C.M., COJOCARU, E., CERNOMAZ, A., LESAN, A., BOERESCU, C., BARBU, R., POPESCU, F., Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres, Mater. Plast., 56(1), 2019, 285-290.

Vancouver
Domokos-Hancu B, Man MA, Trofor AC, Pop CM, Gavrilescu CM, Cojocaru E, Cernomaz A, Lesan A, Boerescu C, Barbu R, Popescu F. Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres. Mater. Plast.[internet]. 2019 Jan;56(1):285-290. Available from: https://doi.org/10.37358/MP.19.1.5167


APA 6th edition
Domokos-Hancu, B., Man, M.A., Trofor, A.C., Pop, C.M., Gavrilescu, C.M., Cojocaru, E.,... Popescu, F. (2019). Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres. Materiale Plastice, 56(1), 285-290. https://doi.org/10.37358/MP.19.1.5167


Harvard
Domokos-Hancu, B., Man, M.A., Trofor, A.C., Pop, C.M., Gavrilescu, C.M., Cojocaru, E., Cernomaz, A., Lesan, A., Boerescu, C., Barbu, R., Popescu, F. (2019). 'Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres', Materiale Plastice, 56(1), pp. 285-290. https://doi.org/10.37358/MP.19.1.5167


IEEE
B. Domokos-Hancu, M.A. Man, A.C. Trofor, C.M. Pop, C.M. Gavrilescu, E. Cojocaru, A. Cernomaz, A. Lesan, C. Boerescu, R. Barbu, F. Popescu, "Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres". Materiale Plastice, vol. 56, no. 1, pp. 285-290, 2019. [online]. https://doi.org/10.37358/MP.19.1.5167


Text
Bianca Domokos-Hancu, Milena Adina Man, Antigona Carmen Trofor, Carmen Monica Pop, Cristina Maria Gavrilescu, Elena Cojocaru, Andrei Cernomaz, Andrei Lesan, Cristian Boerescu, Roxana-Mihaela Barbu, Florina Popescu,
Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres,
Materiale Plastice,
Volume 56, Issue 1,
2019,
Pages 285-290,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.1.5167.
(https://revmaterialeplastice.ro/Articlegs.asp?ID=5167)
Keywords: glass fiber; intratracheal instillation; animal models; occupational exposure


RIS
TY - JOUR
T1 - Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres
A1 - Domokos-Hancu, Bianca
A2 - Man, Milena Adina
A3 - Trofor, Antigona Carmen
A4 - Pop, Carmen Monica
A5 - Gavrilescu, Cristina Maria
A6 - Cojocaru, Elena
A7 - Cernomaz, Andrei
A8 - Lesan, Andrei
A9 - Boerescu, Cristian
A10 - Barbu, Roxana-Mihaela
A11 - Popescu, Florina
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 1
SP - 285
EP - 290
UR - https://doi.org/10.37358/MP.19.1.5167
KW - glass fiber
KW - intratracheal instillation
KW - animal models
KW - occupational exposure
ER -


BibTex
@article{MatPlast2019P285,
author = {Domokos-Hancu Bianca and Man Milena Adina and Trofor Antigona Carmen and Pop Carmen Monica and Gavrilescu Cristina Maria and Cojocaru Elena and Cernomaz Andrei and Lesan Andrei and Boerescu Cristian and Barbu Roxana-Mihaela and Popescu Florina},
title = {Biochemistry in Assessing the Inflammatory Response of the Respiratory System Due to Experimental Exposure to Glass Fibres},
journal = {Materiale Plastice},
volume = {56},
number = {1},
pages = {285-290},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.1.5167},
url = {https://revmaterialeplastice.ro/Articlegs.asp?ID=5167}
}
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