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Materiale Plastice
Cite as: Mater. Plast.
https://doi.org/10.37358/Mat.Plast.1964

OSIM Nr. R102356
ISSN Print 0025-5289
ISSN Online 2668-8220
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Materiale Plastice (Mater. Plast.), Year 2018, Volume 55, Issue 2, 243-246

https://doi.org/10.37358/MP.18.2.5006

Mircea Rivis, Alice G. Simonca, Maria M. Marin, Adina Nora Valeanu, Ileana Rau, Madalina G. Albu Kaya, Emilia Ianes, Ciprian Chelaru, Cristina Dinu Pirvu, Mihaela V. Ghica

New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges


Abstract:
It is well known that periodontitis causes rapid destruction of gingival and bone tissues. Topical treatments are suitable because the drug can be delivered in a proper and controlled concentration. Metronidazole proved to be efficient for patients with aggressive periodontitis. By this study we aimed to obtain spongious drug delivery systems for local periodontitis treatment based on collagen, strontium renalate and metronidazole. Collagen spongious forms were obtained by lyophilisation of composite gels based on collagen:strontium ranelate (50:50) and different concentrations of metronidazole. The obtained spongious forms were characterized by FT-IR, water up-take, optic microscopy and in vitro release of metronidazole. The prepared matrices absorbed a maximum amount of water after 30 min. The most absorbent sample is the reference one (only collagen) which absorbed about 35% water; the adding of metronidazole decrease the water absorption due to its lipophilic behavior. The samples with strontium are more compact and they absorbed less water than the ones without strontium. Because the samples were not cross-linked they degrade during 24 hours of water absorption process. The drug percentage released was influenced by the drug and strontium ranelate concentrations. The analysis performed sponges indicate that these composites can be useful as drug delivery supports.


Keywords:
collagen; metronidazole; strontium ranelate; drug release

Issue: 2018 Volume 55, Issue 2
Pages: 243-246
Publication date: 2018/6/30
https://doi.org/10.37358/MP.18.2.5006
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
RIVIS, M., SIMONCA, A.G., MARIN, M.M., VALEANU, A.N., RAU, I., KAYA, M.G.A., IANES, E., CHELARU, C., PIRVU, C.D., GHICA, M.V., New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges, Mater. Plast., 55(2), 2018, 243-246.

Vancouver
Rivis M, Simonca AG, Marin MM, Valeanu AN, Rau I, Kaya MGA, Ianes E, Chelaru C, Pirvu CD, Ghica MV. New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges. Mater. Plast.[internet]. 2018 Apr;55(2):243-246. Available from: https://doi.org/10.37358/MP.18.2.5006


APA 6th edition
Rivis, M., Simonca, A.G., Marin, M.M., Valeanu, A.N., Rau, I., Kaya, M.G.A.,... Ghica, M.V. (2018). New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges. Materiale Plastice, 55(2), 243-246. https://doi.org/10.37358/MP.18.2.5006


Harvard
Rivis, M., Simonca, A.G., Marin, M.M., Valeanu, A.N., Rau, I., Kaya, M.G.A., Ianes, E., Chelaru, C., Pirvu, C.D., Ghica, M.V. (2018). 'New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges', Materiale Plastice, 55(2), pp. 243-246. https://doi.org/10.37358/MP.18.2.5006


IEEE
M. Rivis, A.G. Simonca, M.M. Marin, A.N. Valeanu, I. Rau, M.G.A. Kaya, E. Ianes, C. Chelaru, C.D. Pirvu, M.V. Ghica, "New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges". Materiale Plastice, vol. 55, no. 2, pp. 243-246, 2018. [online]. https://doi.org/10.37358/MP.18.2.5006


Text
Mircea Rivis, Alice G. Simonca, Maria M. Marin, Adina Nora Valeanu, Ileana Rau, Madalina G. Albu Kaya, Emilia Ianes, Ciprian Chelaru, Cristina Dinu Pirvu, Mihaela V. Ghica,
New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges,
Materiale Plastice,
Volume 55, Issue 2,
2018,
Pages 243-246,
ISSN 2668-8220,
https://doi.org/10.37358/MP.18.2.5006.
(https://revmaterialeplastice.ro/Articlegs.asp?ID=5006)
Keywords: collagen; metronidazole; strontium ranelate; drug release


RIS
TY - JOUR
T1 - New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges
A1 - Rivis, Mircea
A2 - Simonca, Alice G.
A3 - Marin, Maria M.
A4 - Valeanu, Adina Nora
A5 - Rau, Ileana
A6 - Kaya, Madalina G. Albu
A7 - Ianes, Emilia
A8 - Chelaru, Ciprian
A9 - Pirvu, Cristina Dinu
A10 - Ghica, Mihaela V.
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2018
VL - 55
IS - 2
SP - 243
EP - 246
UR - https://doi.org/10.37358/MP.18.2.5006
KW - collagen
KW - metronidazole
KW - strontium ranelate
KW - drug release
ER -


BibTex
@article{MatPlast2018P243,
author = {Rivis Mircea and Simonca Alice G. and Marin Maria M. and Valeanu Adina Nora and Rau Ileana and Kaya Madalina G. Albu and Ianes Emilia and Chelaru Ciprian and Pirvu Cristina Dinu and Ghica Mihaela V.},
title = {New Treatment for Dentistry Regeneration Based on Metronidazole Release from Collagen/Strontium Sponges},
journal = {Materiale Plastice},
volume = {55},
number = {2},
pages = {243-246},
year = {2018},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.18.2.5006},
url = {https://revmaterialeplastice.ro/Articlegs.asp?ID=5006}
}
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