MARINA MELESCANU-IMRE, MIHAELA PANTEA, ALEXANDRA TOTAN, ANA MARIA CRISTINA TANCU, MARIA GREABU, COSMIN TOTAN, TUDOR CLAUDIU SPINU BIOCHEMICAL INTERACTIONS BETWEEN POLYMERIC RESINS USED FOR OCCLUSAL SPLINTS AND SALIVA A PILOT STUDY COMPARING THE CAD/CAM TECHNOLOGY AND THE CONVENTIONAL APPROACH The CAD/CAM technology has been successfully integrated in clinical and laboratory aspects of dental medicine. The present in vitro study focuses on the biochemical interactions between saliva and three types of polymeric resins for occlusal splints. Dental material samples were produced from 3D printed, milled and self-cured resins and were incubated with saliva samples from 20 healthy volunteers. The results showed that the 3D printed and milled polymeric resins did not produce any significant changes in oxidative stress parameters (uric acid, TAC, GGT, OXSR-1) or inflammatory markers (IL-2, IL-6). On the other hand, the self-cured acrylic resin produced a significant decrease in the salivary TAC and uric acid, the most important antioxidants in saliva, affecting the capacity of saliva to protect the oral environment against oxidative stress.