Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Tuta-Sas, Ioana; Borcan, Florin; Sas, Ioan

Ioana Tuta-Sas, Florin Borcan, Ioan Sas

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

Abstract:
Bromelain, a natural substance sourced from pineapples, was found effective in various colds, in preventing heart attack and respectively in excess weight. On the other hand, it is well-known that pineapples juice increases the gastric acidity and respectively the people with hemophilia, internal bleeding must also be very careful in consuming this fruit. The objectives of this study were to obtain and to characterize a drug delivery system used for the transmembrane transfer of bromelain. The samples based on polyurethane matrices with and respectively without bromelain were synthesized and characterized by measurements of pH, encapsulation efficacy, cumulative drug release in a degradative media and in simulated gastric acid, electron microscopy and by modern techniques such as Zetasizer, cytotoxicity assay, and various non-invasive skin irritation assessment. The results indicate the obtaining of polyurethane matrices with mean sizes between 322-342 nm and neutral pH, that have a medium stability against the clusters formation tendency and a medium drug release rate. The non-irritative potential and the results on their cytotoxicity are important evidences that can be used for the further clinical trials of the polyurethane carriers.

Keywords:
cell culture; pH; pineapple; release rate; skin tests; UV-Vis; Zetasizer

Issue: 2023 Volume 60, Issue 1

Pages: 1-12

Publication date: 2023/4/5

https://doi.org/10.37358/MP.23.1.5639

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Citation Styles

Cite this article as:
TUTA-SAS, I., BORCAN, F., SAS, I., Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain, Mater. Plast., 60(1), 2023, 1-12. https://doi.org/10.37358/MP.23.1.5639

Vancouver
Tuta-Sas I, Borcan F, Sas I. Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain. Mater. Plast.[internet]. 2023 Jan;60(1):1-12. Available from: https://doi.org/10.37358/MP.23.1.5639

APA 6th edition
Tuta-Sas, I., Borcan, F. & Sas, I. (2023). Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain. Materiale Plastice, 60(1), 1-12. https://doi.org/10.37358/MP.23.1.5639

Harvard
Tuta-Sas, I., Borcan, F., Sas, I. (2023). 'Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain', Materiale Plastice, 60(1), pp. 1-12. https://doi.org/10.37358/MP.23.1.5639

IEEE
I. Tuta-Sas, F. Borcan, I. Sas, "Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain". Materiale Plastice, vol. 60, no. 1, pp. 1-12, 2023. [online]. https://doi.org/10.37358/MP.23.1.5639

Text
Ioana Tuta-Sas, Florin Borcan, Ioan Sas,
Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain,
Materiale Plastice,
Volume 60, Issue 1,
2023,
Pages 1-12,
ISSN 2668-8220,
https://doi.org/10.37358/MP.23.1.5639.
(https://revmaterialeplastice.ro/Articles.asp?ID=5639)
Keywords: cell culture; pH; pineapple; release rate; skin tests; UV-Vis; Zetasizer

RIS
TY - JOUR
T1 - Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain
A1 - Tuta-Sas, Ioana
A2 - Borcan, Florin
A3 - Sas, Ioan
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2023
VL - 60
IS - 1
SP - 1
EP - 12
UR - https://doi.org/10.37358/MP.23.1.5639
KW - cell culture
KW - pH
KW - pineapple
KW - release rate
KW - skin tests
KW - UV-Vis
KW - Zetasizer
ER -

BibTex
@article{MatPlast2023P1,
author = {Tuta-Sas Ioana and Borcan Florin and Sas Ioan},
title = {Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain},
journal = {Materiale Plastice},
volume = {60},
number = {1},
pages = {1-12},
year = {2023},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.23.1.5639},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5639}
}

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