Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil

Pavaloiu, Ramona-Daniela; Sha'at, Fawzia; Eremia, Mihaela; Hlevca, Cristina; Petrescu, Maria; Sha’at, Mousa; Sevcenco, Claudia

Ramona-Daniela Pavaloiu, Fawzia Sha'at, Mihaela Eremia, Cristina Hlevca, Maria Petrescu, Mousa Sha’at, Claudia Sevcenco

Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil

Abstract:
This study was geared to analyze the preparation methods of pullulan acetate-based nanoparticles loaded with 5-fluorouracil, as well as the potential of pullulan as a biopolymer matrix for obtaining nanoparticles applied in the delivery of anticancer drugs (5-FU). Various methods were used to produce pullulan acetate-based nanoparticles loaded with 5-FU, including nanoprecipitation, modified nanoprecipitation, and double emulsion. Pullulan was previously chemically modified with acetic anhydride, dimethylformamide and pyridine, and yielded pullulan acetate. Pullulan was made using the Aureobasidium pullulans strain through a fermentation procedure. UV-Vis Spectro-photometric and dynamic light scattering (DLS) methods were used to assess entrapment effectiveness, size, and polydispersity index (PDI) of pullulan acetate-based nanoparticles loaded with 5-FU. Based on the properties of the nanoparticles obtained, the optimum preparation method was chosen. The maximum entrapment efficiency was found in pullulan acetate nanoparticles loaded with 5-FU generated by a double emulsion method. The mean hydrodynamic size and PDI of all nanoparticles were adequate. The best formulation showed faster 5-FU release profile in acid phosphate-buffered saline (pH 5) than in phosphate-buffered saline pH 7.4. According to the findings, pullulan derivatives have a great potential for producing nanoparticles that might be used to deliver anticancer medicines.

Keywords:
polymeric nanoparticles; pullulan; antitumor drugs; cancer

Issue: 2022 Volume 59, Issue 2

Pages: 138-144

Publication date: 2022/7/1

https://doi.org/10.37358/MP.22.2.5593

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Citation Styles

Cite this article as:
PAVALOIU, R., SHA'AT, F., EREMIA, M., HLEVCA, C., PETRESCU, M., SHA’AT, M., SEVCENCO, C., Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil, Mater. Plast., 59(2), 2022, 138-144. https://doi.org/10.37358/MP.22.2.5593

Vancouver
Pavaloiu R, Sha'at F, Eremia M, Hlevca C, Petrescu M, Sha’at M, Sevcenco C. Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil. Mater. Plast.[internet]. 2022 Apr;59(2):138-144. Available from: https://doi.org/10.37358/MP.22.2.5593

APA 6th edition
Pavaloiu, R., Sha'at, F., Eremia, M., Hlevca, C., Petrescu, M., Sha’at, M. & Sevcenco, C. (2022). Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil. Materiale Plastice, 59(2), 138-144. https://doi.org/10.37358/MP.22.2.5593

Harvard
Pavaloiu, R., Sha'at, F., Eremia, M., Hlevca, C., Petrescu, M., Sha’at, M., Sevcenco, C. (2022). 'Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil', Materiale Plastice, 59(2), pp. 138-144. https://doi.org/10.37358/MP.22.2.5593

IEEE
R. Pavaloiu, F. Sha'at, M. Eremia, C. Hlevca, M. Petrescu, M. Sha’at, C. Sevcenco, "Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil". Materiale Plastice, vol. 59, no. 2, pp. 138-144, 2022. [online]. https://doi.org/10.37358/MP.22.2.5593

Text
Ramona-Daniela Pavaloiu, Fawzia Sha'at, Mihaela Eremia, Cristina Hlevca, Maria Petrescu, Mousa Sha’at, Claudia Sevcenco,
Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil,
Materiale Plastice,
Volume 59, Issue 2,
2022,
Pages 138-144,
ISSN 2668-8220,
https://doi.org/10.37358/MP.22.2.5593.
(https://revmaterialeplastice.ro/Articles.asp?ID=5593)
Keywords: polymeric nanoparticles; pullulan; antitumor drugs; cancer

RIS
TY - JOUR
T1 - Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil
A1 - Pavaloiu, Ramona-Daniela
A2 - Sha'at, Fawzia
A3 - Eremia, Mihaela
A4 - Hlevca, Cristina
A5 - Petrescu, Maria
A6 - Sha’at, Mousa
A7 - Sevcenco, Claudia
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2022
VL - 59
IS - 2
SP - 138
EP - 144
UR - https://doi.org/10.37358/MP.22.2.5593
KW - polymeric nanoparticles
KW - pullulan
KW - antitumor drugs
KW - cancer
ER -

BibTex
@article{MatPlast2022P138,
author = {Pavaloiu Ramona-Daniela and Sha'at Fawzia and Eremia Mihaela and Hlevca Cristina and Petrescu Maria and Sha’at Mousa and Sevcenco Claudia},
title = {Formulation and Characterisation of Pullulan Acetate Nanoparticles Loaded with 5-Fluorouracil},
journal = {Materiale Plastice},
volume = {59},
number = {2},
pages = {138-144},
year = {2022},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.22.2.5593},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5593}
}

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