Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta

David, Jebarani Joshua; Kandasamy, Ravichandran; Chatterjee, Suvro

Jebarani Joshua David, Ravichandran Kandasamy, Suvro Chatterjee

Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta

Abstract:
Boswellia seratta (BS) is the best herbal medicine to treat Rheumatoid Arthritis (RA), due to its anti-inflammatory and anti-arthritic activity. Delivering BS through an oral drug delivery system has been in effective, because of its enzymatic degradation within the Gastro-Intestinal (GI) tract. In this paper, we develop a gastro retentive approach for delivering BS to avoid high hepatic ﬁrst pass metabolism and optimized buccal patch based on the drug delivery characteristics. There are seven different formulated buccal films of BS that were prepared by the solvent casting method, using mucoadhesive polymers, Poly Vinyl Alcohol (PVA), and Sodium Carboxy Methyl Cellulose (SCMC). These with drug formulation can be represented as PCB. The prepared films were evaluated by various physicochemical properties and characterization studies. Results obtained from physico-chemical properties, in-vitro and ex-vivo studies among all seven patches, PCB5 shows better drug-releasing characteristics. This was further confirmed by FT-IR and XRD characterization studies. Also, the data was statistically analysed using Analysis of Variance (ANOVA).

Keywords:
buccal films; Boswellia seratta; mucoadhesive polymers; Rheumatoid Arthritis (RA)

Issue: 2022 Volume 59, Issue 2

Pages: 40-49

Publication date: 2022/7/1

https://doi.org/10.37358/MP.22.2.5583

Download Pdf Article

This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DAVID, J.J., KANDASAMY, R., CHATTERJEE, S., Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta, Mater. Plast., 59(2), 2022, 40-49. https://doi.org/10.37358/MP.22.2.5583

Vancouver
David JJ, Kandasamy R, Chatterjee S. Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta. Mater. Plast.[internet]. 2022 Apr;59(2):40-49. Available from: https://doi.org/10.37358/MP.22.2.5583

APA 6th edition
David, J.J., Kandasamy, R. & Chatterjee, S. (2022). Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta. Materiale Plastice, 59(2), 40-49. https://doi.org/10.37358/MP.22.2.5583

Harvard
David, J.J., Kandasamy, R., Chatterjee, S. (2022). 'Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta', Materiale Plastice, 59(2), pp. 40-49. https://doi.org/10.37358/MP.22.2.5583

IEEE
J.J. David, R. Kandasamy, S. Chatterjee, "Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta". Materiale Plastice, vol. 59, no. 2, pp. 40-49, 2022. [online]. https://doi.org/10.37358/MP.22.2.5583

Text
Jebarani Joshua David, Ravichandran Kandasamy, Suvro Chatterjee,
Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta,
Materiale Plastice,
Volume 59, Issue 2,
2022,
Pages 40-49,
ISSN 2668-8220,
https://doi.org/10.37358/MP.22.2.5583.
(https://revmaterialeplastice.ro/Articles.asp?ID=5583)
Keywords: buccal films; Boswellia seratta; mucoadhesive polymers; Rheumatoid Arthritis (RA)

RIS
TY - JOUR
T1 - Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta
A1 - David, Jebarani Joshua
A2 - Kandasamy, Ravichandran
A3 - Chatterjee, Suvro
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2022
VL - 59
IS - 2
SP - 40
EP - 49
UR - https://doi.org/10.37358/MP.22.2.5583
KW - buccal films
KW - Boswellia seratta
KW - mucoadhesive polymers
KW - Rheumatoid Arthritis (RA)
ER -

BibTex
@article{MatPlast2022P40,
author = {David Jebarani Joshua and Kandasamy Ravichandran and Chatterjee Suvro},
title = {Development and Evaluation of Polymer Drug Delivery System (PDDS) for Delivery of Boswellia seratta},
journal = {Materiale Plastice},
volume = {59},
number = {2},
pages = {40-49},
year = {2022},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.22.2.5583},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5583}
}

Download article Citations: