The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials

Marin, Maria-Minodora; Kaya, Madalina Georgiana Albu; Vlasceanu, George Mihail; Ghitman, Jana; Radu, Ionut Cristian; Iovu, Horia

Maria-Minodora Marin, Madalina Georgiana Albu Kaya, George Mihail Vlasceanu, Jana Ghitman, Ionut Cristian Radu, Horia Iovu

The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials

Abstract:
Type II collagen has been perceived as the indispensable element and plays a crucial role in cartilage tissue engineering. Thus, materials based on type II collagen have drawn farther attention in both academic and research for developing new systems for the cartilage regeneration. The disadvantage of using type II collagen as a biomaterial for tissue repairing is its reduced biomechanical properties. This can be solved by physical, enzymatic or chemical cross-linking processes, which provide biomaterials with the required mechanical properties for medical applications. To enhance type II collagen properties, crosslinked collagen scaffolds with different cross-linking agents were prepared by freeze-drying technique. The present research work studied the synthesis of type II collagen biomaterials with and without crosslinking agents. Scaffolds morphology was observed by MicroCT, showing in all cases an appropriate microstructure for biological applications, and the mechanical studies were performed using compressive tests. DSC showed an increase in denaturation temperature with an increase in cross-linking agent concentration. FTIR suggested that the secondary structure of collagen is not affected after the cross-linking; supplementary, to confirm the characteristic triple-helix conformation of collagen, the CD investigation was performed. The results showed that the physical-chemical properties of type II collagen were improved by cross-linking treatments.

Keywords:
type II collagen; cartilage; crosslinking agents

Issue: 2020 Volume 57, Issue 4

Pages: 166-180

Publication date: 2021/1/6

https://doi.org/10.37358/MP.20.4.5416

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Citation Styles

Cite this article as:
MARIN, M., KAYA, M.G.A., VLASCEANU, G.M., GHITMAN, J., RADU, I.C., IOVU, H., The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials, Mater. Plast., 57(4), 2020, 166-180. https://doi.org/10.37358/MP.20.4.5416

Vancouver
Marin M, Kaya MGA, Vlasceanu GM, Ghitman J, Radu IC, Iovu H. The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials. Mater. Plast.[internet]. 2020 Dec;57(4):166-180. Available from: https://doi.org/10.37358/MP.20.4.5416

APA 6th edition
Marin, M., Kaya, M.G.A., Vlasceanu, G.M., Ghitman, J., Radu, I.C. & Iovu, H. (2020). The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials. Materiale Plastice, 57(4), 166-180. https://doi.org/10.37358/MP.20.4.5416

Harvard
Marin, M., Kaya, M.G.A., Vlasceanu, G.M., Ghitman, J., Radu, I.C., Iovu, H. (2020). 'The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials', Materiale Plastice, 57(4), pp. 166-180. https://doi.org/10.37358/MP.20.4.5416

IEEE
M. Marin, M.G.A. Kaya, G.M. Vlasceanu, J. Ghitman, I.C. Radu, H. Iovu, "The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials". Materiale Plastice, vol. 57, no. 4, pp. 166-180, 2020. [online]. https://doi.org/10.37358/MP.20.4.5416

Text
Maria-Minodora Marin, Madalina Georgiana Albu Kaya, George Mihail Vlasceanu, Jana Ghitman, Ionut Cristian Radu, Horia Iovu,
The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials,
Materiale Plastice,
Volume 57, Issue 4,
2020,
Pages 166-180,
ISSN 2668-8220,
https://doi.org/10.37358/MP.20.4.5416.
(https://revmaterialeplastice.ro/Articles.asp?ID=5416)
Keywords: type II collagen; cartilage; crosslinking agents

RIS
TY - JOUR
T1 - The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials
A1 - Marin, Maria-Minodora
A2 - Kaya, Madalina Georgiana Albu
A3 - Vlasceanu, George Mihail
A4 - Ghitman, Jana
A5 - Radu, Ionut Cristian
A6 - Iovu, Horia
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2020
VL - 57
IS - 4
SP - 166
EP - 180
UR - https://doi.org/10.37358/MP.20.4.5416
KW - type II collagen
KW - cartilage
KW - crosslinking agents
ER -

BibTex
@article{MatPlast2020P166,
author = {Marin Maria-Minodora and Kaya Madalina Georgiana Albu and Vlasceanu George Mihail and Ghitman Jana and Radu Ionut Cristian and Iovu Horia},
title = {The Effect of Crosslinking Agents on the Properties of Type II Collagen Biomaterials},
journal = {Materiale Plastice},
volume = {57},
number = {4},
pages = {166-180},
year = {2020},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.20.4.5416},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5416}
}

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