A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Himiniuc, Loredana; Agop, Maricel; Ghizdovat, Vlad; Paun, Maria-Alexandra; Paun, Vladimir-Alexandru; Baciu, Constantin; Paun, Viorel-Puiu; Toma, Bogdan

Loredana Himiniuc, Maricel Agop, Vlad Ghizdovat, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Constantin Baciu, Viorel-Puiu Paun, Bogdan Toma

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Abstract:
Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient's comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gynecology have been discussed.

Keywords:
controlled drug release; drug delivery systems; amphiphilic matrix; nonsteroidal anti-inflammatory drugs; diclofenac

Issue: 2020 Volume 57, Issue 4

Pages: 155-165

Publication date: 2021/1/6

https://doi.org/10.37358/MP.20.4.5415

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
HIMINIUC, L., AGOP, M., GHIZDOVAT, V., PAUN, M., PAUN, V., BACIU, C., PAUN, V., TOMA, B., A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives, Mater. Plast., 57(4), 2020, 155-165. https://doi.org/10.37358/MP.20.4.5415

Vancouver
Himiniuc L, Agop M, Ghizdovat V, Paun M, Paun V, Baciu C, Paun V, Toma B. A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives. Mater. Plast.[internet]. 2020 Dec;57(4):155-165. Available from: https://doi.org/10.37358/MP.20.4.5415

APA 6th edition
Himiniuc, L., Agop, M., Ghizdovat, V., Paun, M., Paun, V., Baciu, C., Paun, V. & Toma, B. (2020). A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives. Materiale Plastice, 57(4), 155-165. https://doi.org/10.37358/MP.20.4.5415

Harvard
Himiniuc, L., Agop, M., Ghizdovat, V., Paun, M., Paun, V., Baciu, C., Paun, V., Toma, B. (2020). 'A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives', Materiale Plastice, 57(4), pp. 155-165. https://doi.org/10.37358/MP.20.4.5415

IEEE
L. Himiniuc, M. Agop, V. Ghizdovat, M. Paun, V. Paun, C. Baciu, V. Paun, B. Toma, "A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives". Materiale Plastice, vol. 57, no. 4, pp. 155-165, 2020. [online]. https://doi.org/10.37358/MP.20.4.5415

Text
Loredana Himiniuc, Maricel Agop, Vlad Ghizdovat, Maria-Alexandra Paun, Vladimir-Alexandru Paun, Constantin Baciu, Viorel-Puiu Paun, Bogdan Toma,
A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives,
Materiale Plastice,
Volume 57, Issue 4,
2020,
Pages 155-165,
ISSN 2668-8220,
https://doi.org/10.37358/MP.20.4.5415.
(https://revmaterialeplastice.ro/Articles.asp?ID=5415)
Keywords: controlled drug release; drug delivery systems; amphiphilic matrix; nonsteroidal anti-inflammatory drugs; diclofenac

RIS
TY - JOUR
T1 - A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives
A1 - Himiniuc, Loredana
A2 - Agop, Maricel
A3 - Ghizdovat, Vlad
A4 - Paun, Maria-Alexandra
A5 - Paun, Vladimir-Alexandru
A6 - Baciu, Constantin
A7 - Paun, Viorel-Puiu
A8 - Toma, Bogdan
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2020
VL - 57
IS - 4
SP - 155
EP - 165
UR - https://doi.org/10.37358/MP.20.4.5415
KW - controlled drug release
KW - drug delivery systems
KW - amphiphilic matrix
KW - nonsteroidal anti-inflammatory drugs
KW - diclofenac
ER -

BibTex
@article{MatPlast2020P155,
author = {Himiniuc Loredana and Agop Maricel and Ghizdovat Vlad and Paun Maria-Alexandra and Paun Vladimir-Alexandru and Baciu Constantin and Paun Viorel-Puiu and Toma Bogdan},
title = {A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives},
journal = {Materiale Plastice},
volume = {57},
number = {4},
pages = {155-165},
year = {2020},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.20.4.5415},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5415}
}

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