Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment

Menezes, Alicia; Lysetty, Shanthi; Naha, Anup

Alicia Menezes, Shanthi Lysetty, Anup Naha

Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment

Abstract:
Lercanidipine has found to be effective in lowering blood pressure among the potent calcium channel blockers, through its action on L- type calcium channels. However, the major disadvantage associated with Lercanidipine is, it is a BCS class II drug having low solubility bioavailability is around 10% through oral route due of extensive first pass metabolism. The present study is aimed to prepare and evaluate polymeric nanoparticles of Lercanidipine using a combination of two bottom down techniques, High speed homogenizer and Probe sonication. Preformulation studies like, DSC, FTIR using surfactants such as Tween 80, Sodium Lauryl sulphate, Polyvinyl Alcohol, singely and in combination were used. A full factorial method was utilized to study the effect of various factors such as surfactant concentration, homogenization speed, sonication amplitude and sonication time on Lercanidipine nanoparticles in two levels. Optimized nanoparticles (with PVA as surfactant) showed an average particle size of 141 nm, PDI 0.248 and zeta potential +6.46. Formulation was further optimized using Design Expert 10 software. Optimized formulation was found to be stable during 3 months stability studies as per ICH guidelines.

Keywords:
lercanidpine; polymeric nanoparticles; bioavailability; design of expert; optimization

Issue: 2020 Volume 57, Issue 3

Pages: 1-18

Publication date: 2020/9/30

https://doi.org/10.37358/MP.20.3.5375

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Citation Styles

Cite this article as:
MENEZES, A., LYSETTY, S., NAHA, A., Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment, Mater. Plast., 57(3), 2020, 1-18. https://doi.org/10.37358/MP.20.3.5375

Vancouver
Menezes A, Lysetty S, Naha A. Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment. Mater. Plast.[internet]. 2020 Jul;57(3):1-18. Available from: https://doi.org/10.37358/MP.20.3.5375

APA 6th edition
Menezes, A., Lysetty, S. & Naha, A. (2020). Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment. Materiale Plastice, 57(3), 1-18. https://doi.org/10.37358/MP.20.3.5375

Harvard
Menezes, A., Lysetty, S., Naha, A. (2020). 'Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment', Materiale Plastice, 57(3), pp. 1-18. https://doi.org/10.37358/MP.20.3.5375

IEEE
A. Menezes, S. Lysetty, A. Naha, "Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment". Materiale Plastice, vol. 57, no. 3, pp. 1-18, 2020. [online]. https://doi.org/10.37358/MP.20.3.5375

Text
Alicia Menezes, Shanthi Lysetty, Anup Naha,
Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment,
Materiale Plastice,
Volume 57, Issue 3,
2020,
Pages 1-18,
ISSN 2668-8220,
https://doi.org/10.37358/MP.20.3.5375.
(https://revmaterialeplastice.ro/Articles.asp?ID=5375)
Keywords: lercanidpine; polymeric nanoparticles; bioavailability; design of expert; optimization

RIS
TY - JOUR
T1 - Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment
A1 - Menezes, Alicia
A2 - Lysetty, Shanthi
A3 - Naha, Anup
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2020
VL - 57
IS - 3
SP - 1
EP - 18
UR - https://doi.org/10.37358/MP.20.3.5375
KW - lercanidpine
KW - polymeric nanoparticles
KW - bioavailability
KW - design of expert
KW - optimization
ER -

BibTex
@article{MatPlast2020P1,
author = {Menezes Alicia and Lysetty Shanthi and Naha Anup},
title = {Formulation of Polymeric Nanoparticles of Lercanidipine by Two Bottom Down Techniques Optimized by Design of Experiment},
journal = {Materiale Plastice},
volume = {57},
number = {3},
pages = {1-18},
year = {2020},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.20.3.5375},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5375}
}

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