Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer

Mares, Cristian; Popescu, Razvan-Ionut; Petca, Aida; Maru, Nicoleta; Dogaroiu, catalin; Petca, Razvan-Cosmin

Cristian Mares, Razvan-Ionut Popescu, Aida Petca, Nicoleta Maru,catalin Dogaroiu, Razvan-Cosmin Petca

Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer

Abstract:
Bisphenol-A (BPA) is widely spread among the endocrine-disrupting chemicals (EDCs). Different hormone derivates or various organochlorinated pesticides are industrial human-made “plastics.” EDCs are ubiquitary used in the modern world, and their impact on human health has been intensively studied in the last decades. BPA is used as a representative model for endocrine disruption mechanisms; it represents a critical element of producing polycarbonate plastics and epoxy resins, necessary for the manufacture of beverage or food containers, various personal-care products or dental industry products. Environmental exposure to BPA or other EDCs has resulted in functional or morphological drastically alterations of the genital tract or mammary gland that lead to earlier onset of different diseases, reduce fertility, or inducing prostate cancer. All the above have been observed via multiple in vitro analyses on human cells or in vitro analyses on animal models, especially rats. BPA causes prostate cancer through a sum o mechanisms. It increases the activation of various signaling pathways (Erk or Akt kinase), steroidal receptors recruiting chromatin, derived activity of different histone-modifying enzymes, transcription of various androgen receptor mutants detected in prostate cancer or acting via a pro-inflammatory mechanism that leads to prostate cancer progression once installed. Other EDCs such as different dioxins, cadmium, or inorganic arsenic are also incriminating in the neoplastic transformation of the prostate. This review aims to evaluate the current knowledge on this topic. Most of the authors agree on the carcinogenetic effects of these compounds. Extensive in vivo research on humans is imperative for a better and more accurate understanding of “plastics” impact.

Keywords:
Bisphenol-A; BPA; polycarbonate plastics; EDCs; dioxins; prostate cancerons

Issue: 2020 Volume 57, Issue 2

Pages: 239-252

Publication date: 2019/7/1

https://doi.org/10.37358/MP.20.2.5370

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MARES, C., POPESCU, R., PETCA, A., MARU, N., DOGAROIU, C., PETCA, R., Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer, Mater. Plast., 57(2), 2020, 239-252. https://doi.org/10.37358/MP.20.2.5370

Vancouver
Mares C, Popescu R, Petca A, Maru N, Dogaroiu c, Petca R. Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer. Mater. Plast.[internet]. 2020 Apr;57(2):239-252. Available from: https://doi.org/10.37358/MP.20.2.5370

APA 6th edition
Mares, C., Popescu, R., Petca, A., Maru, N., Dogaroiu, c. & Petca, R. (2020). Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer. Materiale Plastice, 57(2), 239-252. https://doi.org/10.37358/MP.20.2.5370

Harvard
Mares, C., Popescu, R., Petca, A., Maru, N., Dogaroiu, c., Petca, R. (2020). 'Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer', Materiale Plastice, 57(2), pp. 239-252. https://doi.org/10.37358/MP.20.2.5370

IEEE
C. Mares, R. Popescu, A. Petca, N. Maru, c. Dogaroiu, R. Petca, "Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer". Materiale Plastice, vol. 57, no. 2, pp. 239-252, 2020. [online]. https://doi.org/10.37358/MP.20.2.5370

Text
Cristian Mares, Razvan-Ionut Popescu, Aida Petca, Nicoleta Maru,catalin Dogaroiu, Razvan-Cosmin Petca,
Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer,
Materiale Plastice,
Volume 57, Issue 2,
2020,
Pages 239-252,
ISSN 2668-8220,
https://doi.org/10.37358/MP.20.2.5370.
(https://revmaterialeplastice.ro/Articles.asp?ID=5370)
Keywords: Bisphenol-A; BPA; polycarbonate plastics; EDCs; dioxins; prostate cancerons

RIS
TY - JOUR
T1 - Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer
A1 - Mares, Cristian
A2 - Popescu, Razvan-Ionut
A3 - Petca, Aida
A4 - Maru, Nicoleta
A5 - Dogaroiu, catalin
A6 - Petca, Razvan-Cosmin
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2020
VL - 57
IS - 2
SP - 239
EP - 252
UR - https://doi.org/10.37358/MP.20.2.5370
KW - Bisphenol-A
KW - BPA
KW - polycarbonate plastics
KW - EDCs
KW - dioxins
KW - prostate cancerons
ER -

BibTex
@article{MatPlast2020P239,
author = {Mares Cristian and Popescu Razvan-Ionut and Petca Aida and Maru Nicoleta and Dogaroiu catalin and Petca Razvan-Cosmin},
title = {Bisphenol-A and other Plastics: Review of Endocrine Disrupting Effects on Prostate Cancer},
journal = {Materiale Plastice},
volume = {57},
number = {2},
pages = {239-252},
year = {2020},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.20.2.5370},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5370}
}

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