Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine

Ionescu (Filip), Oana; Ciocilteu, Maria Viorica; Manda, Costel Valentin; Neacsu, Ionela Andreea; Ficai, Anton; Amzoiu, Emilia; Stiolica, Adina Turcu; Croitoru, Octavian; Neamtu, Johny

Oana Ionescu (Filip), Maria Viorica Ciocilteu, Costel Valentin Manda, Ionela Andreea Neacsu, Anton Ficai, Emilia Amzoiu, Adina Turcu Stiolica, Octavian Croitoru, Johny Neamtu

Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine

Abstract:
The purpose of this study was the synthesis of two types of biodegradable materials with synthetic polymers (PLGA) or natural polymers (collagen) and hydroxyapatite, followed by determination of the encapsulation percentage of the drug in the polymer. Regardless of the chosen method, the percentage of the encapsulated drug was found to be quite high: 15.92% in the Coll-HA-Genta material and 19.59% respectively in the PLGA-Genta biocomposite. The therapeutic value of gentamicin was improved by encapsulating it in delivery systems, contributing to sustained release for a long time (about 30 days).

Keywords:
collagen-hidroxiapatite; PLGA-gentamicin; biocomposites; biodegradability

Issue: 2019 Volume 56, Issue 3

Pages: 534-527

Publication date: 2019/9/30

https://doi.org/10.37358/MP.19.3.5224

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
IONESCU (FILIP), O., CIOCILTEU, M.V., MANDA, C.V., NEACSU, I.A., FICAI, A., AMZOIU, E., STIOLICA, A.T., CROITORU, O., NEAMTU, J., Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine, Mater. Plast., 56(3), 2019, 534-527. https://doi.org/10.37358/MP.19.3.5224

Vancouver
Ionescu (Filip) O, Ciocilteu MV, Manda CV, Neacsu IA, Ficai A, Amzoiu E, Stiolica AT, Croitoru O, Neamtu J. Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine. Mater. Plast.[internet]. 2019 Jul;56(3):534-527. Available from: https://doi.org/10.37358/MP.19.3.5224

APA 6th edition
Ionescu (Filip), O., Ciocilteu, M.V., Manda, C.V., Neacsu, I.A., Ficai, A., Amzoiu, E.,... Neamtu, J. (2019). Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine. Materiale Plastice, 56(3), 534-527. https://doi.org/10.37358/MP.19.3.5224

Harvard
Ionescu (Filip), O., Ciocilteu, M.V., Manda, C.V., Neacsu, I.A., Ficai, A., Amzoiu, E., Stiolica, A.T., Croitoru, O., Neamtu, J. (2019). 'Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine', Materiale Plastice, 56(3), pp. 534-527. https://doi.org/10.37358/MP.19.3.5224

IEEE
O. Ionescu(Filip), M.V. Ciocilteu, C.V. Manda, I.A. Neacsu, A. Ficai, E. Amzoiu, A.T. Stiolica, O. Croitoru, J. Neamtu, "Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine". Materiale Plastice, vol. 56, no. 3, pp. 534-527, 2019. [online]. https://doi.org/10.37358/MP.19.3.5224

Text
Oana Ionescu (Filip), Maria Viorica Ciocilteu, Costel Valentin Manda, Ionela Andreea Neacsu, Anton Ficai, Emilia Amzoiu, Adina Turcu Stiolica, Octavian Croitoru, Johny Neamtu,
Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine,
Materiale Plastice,
Volume 56, Issue 3,
2019,
Pages 534-527,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.3.5224.
(https://revmaterialeplastice.ro/Articles.asp?ID=5224)
Keywords: collagen-hidroxiapatite; PLGA-gentamicin; biocomposites; biodegradability

RIS
TY - JOUR
T1 - Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine
A1 - Ionescu (Filip), Oana
A2 - Ciocilteu, Maria Viorica
A3 - Manda, Costel Valentin
A4 - Neacsu, Ionela Andreea
A5 - Ficai, Anton
A6 - Amzoiu, Emilia
A7 - Stiolica, Adina Turcu
A8 - Croitoru, Octavian
A9 - Neamtu, Johny
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 3
SP - 534
EP - 527
UR - https://doi.org/10.37358/MP.19.3.5224
KW - collagen-hidroxiapatite
KW - PLGA-gentamicin
KW - biocomposites
KW - biodegradability
ER -

BibTex
@article{MatPlast2019P534,
author = {Ionescu (Filip) Oana and Ciocilteu Maria Viorica and Manda Costel Valentin and Neacsu Ionela Andreea and Ficai Anton and Amzoiu Emilia and Stiolica Adina Turcu and Croitoru Octavian and Neamtu Johny},
title = {Bone - Graft Delivery Systems of Type PLGA- gentamicin and Collagen - hydroxyapatite - gentamicine},
journal = {Materiale Plastice},
volume = {56},
number = {3},
pages = {534-527},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.3.5224},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5224}
}

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