Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide

Banu, Elena Ariela; Duceac, Letitia Doina; Mitrea, Geta; Ciuhodaru, Madalina Irina; Ichim, Daniela Luminita; Ciomaga, Irina Mihaela; Goroftei, Roxana Elena Bogdan; Constantin, Marcu; Baciu, Ginel

Elena Ariela Banu, Letitia Doina Duceac, Geta Mitrea, Madalina Irina Ciuhodaru, Daniela Luminita Ichim, Irina Mihaela Ciomaga, Roxana Elena Bogdan Goroftei, Marcu Constantin, Ginel Baciu

Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide

Abstract:
The usual treatment for tuberculosis is difficult by its long-term therapy, raised dosing frequency and adverse effects of anti-tuberculosis drugs. Anionic clays, also called layered double hydroxides are a class of hydrotalcite like structures having high compositional variety and being able to self-assembly in the presence of drug molecules. The work refers to the development of nanohybrid materials like delivery systems that intercalates isonicotinic acid hydrazide, known as isoniazid anti-tuberculosis drug, into layered structure of hydrotalcite compounds. Loaded drug molecules of isoniazid were proved to be released in a controlled way from the as synthesized nanostructure in a simulated buffer solution. The obtained sample was characterized by advanced techniques thus demonstrating the inclusion of isoniazid antibiotic between hydrotalcite sheets. These results revealed important expectations for further researches of these organic-inorganic nanocomposites for tuberculosis treatment.

Keywords:
nanohybrids; tuberculosis; Koch bacillus; infection; newborn; fetus; mother; infant; epidemiology

Issue: 2019 Volume 56, Issue 2

Pages: 392-395

Publication date: 2019/6/30

https://doi.org/10.37358/MP.19.2.5192

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
BANU, E.A., DUCEAC, L.D., MITREA, G., CIUHODARU, M.I., ICHIM, D.L., CIOMAGA, I.M., GOROFTEI, R.E.B., CONSTANTIN, M., BACIU, G., Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide, Mater. Plast., 56(2), 2019, 392-395. https://doi.org/10.37358/MP.19.2.5192

Vancouver
Banu EA, Duceac LD, Mitrea G, Ciuhodaru MI, Ichim DL, Ciomaga IM, Goroftei REB, Constantin M, Baciu G. Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide. Mater. Plast.[internet]. 2019 Apr;56(2):392-395. Available from: https://doi.org/10.37358/MP.19.2.5192

APA 6th edition
Banu, E.A., Duceac, L.D., Mitrea, G., Ciuhodaru, M.I., Ichim, D.L., Ciomaga, I.M.,... Baciu, G. (2019). Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide. Materiale Plastice, 56(2), 392-395. https://doi.org/10.37358/MP.19.2.5192

Harvard
Banu, E.A., Duceac, L.D., Mitrea, G., Ciuhodaru, M.I., Ichim, D.L., Ciomaga, I.M., Goroftei, R.E.B., Constantin, M., Baciu, G. (2019). 'Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide', Materiale Plastice, 56(2), pp. 392-395. https://doi.org/10.37358/MP.19.2.5192

IEEE
E.A. Banu, L.D. Duceac, G. Mitrea, M.I. Ciuhodaru, D.L. Ichim, I.M. Ciomaga, R.E.B. Goroftei, M. Constantin, G. Baciu, "Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide". Materiale Plastice, vol. 56, no. 2, pp. 392-395, 2019. [online]. https://doi.org/10.37358/MP.19.2.5192

Text
Elena Ariela Banu, Letitia Doina Duceac, Geta Mitrea, Madalina Irina Ciuhodaru, Daniela Luminita Ichim, Irina Mihaela Ciomaga, Roxana Elena Bogdan Goroftei, Marcu Constantin, Ginel Baciu,
Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide,
Materiale Plastice,
Volume 56, Issue 2,
2019,
Pages 392-395,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.2.5192.
(https://revmaterialeplastice.ro/Articles.asp?ID=5192)
Keywords: nanohybrids; tuberculosis; Koch bacillus; infection; newborn; fetus; mother; infant; epidemiology

RIS
TY - JOUR
T1 - Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide
A1 - Banu, Elena Ariela
A2 - Duceac, Letitia Doina
A3 - Mitrea, Geta
A4 - Ciuhodaru, Madalina Irina
A5 - Ichim, Daniela Luminita
A6 - Ciomaga, Irina Mihaela
A7 - Goroftei, Roxana Elena Bogdan
A8 - Constantin, Marcu
A9 - Baciu, Ginel
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 2
SP - 392
EP - 395
UR - https://doi.org/10.37358/MP.19.2.5192
KW - nanohybrids
KW - tuberculosis
KW - Koch bacillus
KW - infection
KW - newborn
KW - fetus
KW - mother
KW - infant
KW - epidemiology
ER -

BibTex
@article{MatPlast2019P392,
author = {Banu Elena Ariela and Duceac Letitia Doina and Mitrea Geta and Ciuhodaru Madalina Irina and Ichim Daniela Luminita and Ciomaga Irina Mihaela and Goroftei Roxana Elena Bogdan and Constantin Marcu and Baciu Ginel},
title = {Synthesis and Physico-chemical Characterization of Nanohybrid Materials Based on Isonicotinic Acid Hydrazide},
journal = {Materiale Plastice},
volume = {56},
number = {2},
pages = {392-395},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.2.5192},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5192}
}

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