Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria

Duceac, Letitia Doina; Mitrea, Geta; Banu, Elena Ariela; Ciuhodaru, Madalina Irina; Ciomaga, Irina Mihaela; Ichim, Daniela Luminita; Constantin, Marcu; Luca, Alina Costina

Letitia Doina Duceac, Geta Mitrea, Elena Ariela Banu, Madalina Irina Ciuhodaru, Irina Mihaela Ciomaga, Daniela Luminita Ichim, Marcu Constantin, Alina Costina Luca

Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria

Abstract:
Carbapenem antibiotics resistance is a medical threat in antibacterial therapy as the pathogen resistant strains easily evolve a multi-drug resistance action to other incurable agents. The protective transport of current antibiotic molecules using nano-carriers initiates a huge approach in the antibacterial therapy, allowing the nanohybrids to defeat all these health threat pathogen agents. Chitosan is a linear cationic polysaccharide being often used in medical area as a biocompatible encapsulating agent in antibiotic delivery nanosystems. This work refers to encapsulation of imipenem into biodegradable chitosan nanoparticles in order to destroy antibiotic-resistant bacteria and limit the microbial adhesion and multiplication. Nanoparticles were prepared by ion gelation method using tripolyphosphate as cross linking agent. The obtained hybrid nanocapsules were then characterized and evaluated as a potential nano-device to beat antimicrobial resistance.

Keywords:
nanohybrids; carbapenem; infection; multi-drug resistant germs; newborn; fetus; mother; infant; epidemiology

Issue: 2019 Volume 56, Issue 2

Pages: 388-391

Publication date: 2019/6/30

https://doi.org/10.37358/MP.19.2.5191

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
DUCEAC, L.D., MITREA, G., BANU, E.A., CIUHODARU, M.I., CIOMAGA, I.M., ICHIM, D.L., CONSTANTIN, M., LUCA, A.C., Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria, Mater. Plast., 56(2), 2019, 388-391. https://doi.org/10.37358/MP.19.2.5191

Vancouver
Duceac LD, Mitrea G, Banu EA, Ciuhodaru MI, Ciomaga IM, Ichim DL, Constantin M, Luca AC. Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria. Mater. Plast.[internet]. 2019 Apr;56(2):388-391. Available from: https://doi.org/10.37358/MP.19.2.5191

APA 6th edition
Duceac, L.D., Mitrea, G., Banu, E.A., Ciuhodaru, M.I., Ciomaga, I.M., Ichim, D.L., Constantin, M. & Luca, A.C. (2019). Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria. Materiale Plastice, 56(2), 388-391. https://doi.org/10.37358/MP.19.2.5191

Harvard
Duceac, L.D., Mitrea, G., Banu, E.A., Ciuhodaru, M.I., Ciomaga, I.M., Ichim, D.L., Constantin, M., Luca, A.C. (2019). 'Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria', Materiale Plastice, 56(2), pp. 388-391. https://doi.org/10.37358/MP.19.2.5191

IEEE
L.D. Duceac, G. Mitrea, E.A. Banu, M.I. Ciuhodaru, I.M. Ciomaga, D.L. Ichim, M. Constantin, A.C. Luca, "Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria". Materiale Plastice, vol. 56, no. 2, pp. 388-391, 2019. [online]. https://doi.org/10.37358/MP.19.2.5191

Text
Letitia Doina Duceac, Geta Mitrea, Elena Ariela Banu, Madalina Irina Ciuhodaru, Irina Mihaela Ciomaga, Daniela Luminita Ichim, Marcu Constantin, Alina Costina Luca,
Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria,
Materiale Plastice,
Volume 56, Issue 2,
2019,
Pages 388-391,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.2.5191.
(https://revmaterialeplastice.ro/Articles.asp?ID=5191)
Keywords: nanohybrids; carbapenem; infection; multi-drug resistant germs; newborn; fetus; mother; infant; epidemiology

RIS
TY - JOUR
T1 - Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria
A1 - Duceac, Letitia Doina
A2 - Mitrea, Geta
A3 - Banu, Elena Ariela
A4 - Ciuhodaru, Madalina Irina
A5 - Ciomaga, Irina Mihaela
A6 - Ichim, Daniela Luminita
A7 - Constantin, Marcu
A8 - Luca, Alina Costina
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 2
SP - 388
EP - 391
UR - https://doi.org/10.37358/MP.19.2.5191
KW - nanohybrids
KW - carbapenem
KW - infection
KW - multi-drug resistant germs
KW - newborn
KW - fetus
KW - mother
KW - infant
KW - epidemiology
ER -

BibTex
@article{MatPlast2019P388,
author = {Duceac Letitia Doina and Mitrea Geta and Banu Elena Ariela and Ciuhodaru Madalina Irina and Ciomaga Irina Mihaela and Ichim Daniela Luminita and Constantin Marcu and Luca Alina Costina},
title = {Synthesis and Characterization of Carbapenem Based Nanohybrids as Antimicrobial Agents for Multidrug Resistant Bacteria},
journal = {Materiale Plastice},
volume = {56},
number = {2},
pages = {388-391},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.2.5191},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5191}
}

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