Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen

Stamate, Monica Iliuta; Stamate, Ciprian; Timofte, Daniel; Ciuntu, Bogdan; Gafitanu, Carmen; Stefanache, Alina; Ochiuz, Lacramioara

Monica Iliuta Stamate, Ciprian Stamate, Daniel Timofte, Bogdan Ciuntu, Carmen Gafitanu, Alina Stefanache, Lacramioara Ochiuz

Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen

Abstract:
In this study, the effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied. Many polymers are added in formulation of compressed tablets in order to improve the physicochemical characteristics of the drug release system. The samples were made in the form of cylindrical tablet about 9 mm in diameter, containing different mixtures of drug substances and excipients acording to seven formulations. Cylindrical tablets containing mixtures of ketoprofen and various types of polymers are made by direct compression method. Among the binders used were a series of different polymers like Kollidon va 64, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. Mechanical parameters such as hardness, mechanical strenght, friability and roughness were studied in order to determine how they are influenced by polymeric binders.

Keywords:
polymers; compressed tablet; hardeness; roughness

Issue: 2019 Volume 56, Issue 1

Pages: 239-244

Publication date: 2019/3/30

https://doi.org/10.37358/MP.19.1.5159

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
STAMATE, M.I., STAMATE, C., TIMOFTE, D., CIUNTU, B., GAFITANU, C., STEFANACHE, A., OCHIUZ, L., Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen, Mater. Plast., 56(1), 2019, 239-244. https://doi.org/10.37358/MP.19.1.5159

Vancouver
Stamate MI, Stamate C, Timofte D, Ciuntu B, Gafitanu C, Stefanache A, Ochiuz L. Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen. Mater. Plast.[internet]. 2019 Jan;56(1):239-244. Available from: https://doi.org/10.37358/MP.19.1.5159

APA 6th edition
Stamate, M.I., Stamate, C., Timofte, D., Ciuntu, B., Gafitanu, C., Stefanache, A. & Ochiuz, L. (2019). Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen. Materiale Plastice, 56(1), 239-244. https://doi.org/10.37358/MP.19.1.5159

Harvard
Stamate, M.I., Stamate, C., Timofte, D., Ciuntu, B., Gafitanu, C., Stefanache, A., Ochiuz, L. (2019). 'Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen', Materiale Plastice, 56(1), pp. 239-244. https://doi.org/10.37358/MP.19.1.5159

IEEE
M.I. Stamate, C. Stamate, D. Timofte, B. Ciuntu, C. Gafitanu, A. Stefanache, L. Ochiuz, "Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen". Materiale Plastice, vol. 56, no. 1, pp. 239-244, 2019. [online]. https://doi.org/10.37358/MP.19.1.5159

Text
Monica Iliuta Stamate, Ciprian Stamate, Daniel Timofte, Bogdan Ciuntu, Carmen Gafitanu, Alina Stefanache, Lacramioara Ochiuz,
Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen,
Materiale Plastice,
Volume 56, Issue 1,
2019,
Pages 239-244,
ISSN 2668-8220,
https://doi.org/10.37358/MP.19.1.5159.
(https://revmaterialeplastice.ro/Articles.asp?ID=5159)
Keywords: polymers; compressed tablet; hardeness; roughness

RIS
TY - JOUR
T1 - Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen
A1 - Stamate, Monica Iliuta
A2 - Stamate, Ciprian
A3 - Timofte, Daniel
A4 - Ciuntu, Bogdan
A5 - Gafitanu, Carmen
A6 - Stefanache, Alina
A7 - Ochiuz, Lacramioara
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2019
VL - 56
IS - 1
SP - 239
EP - 244
UR - https://doi.org/10.37358/MP.19.1.5159
KW - polymers
KW - compressed tablet
KW - hardeness
KW - roughness
ER -

BibTex
@article{MatPlast2019P239,
author = {Stamate Monica Iliuta and Stamate Ciprian and Timofte Daniel and Ciuntu Bogdan and Gafitanu Carmen and Stefanache Alina and Ochiuz Lacramioara},
title = {Effect of Polymers on the Pharmaco-mechanical Properties of Direct Compressed Tablets with Ketoprofen},
journal = {Materiale Plastice},
volume = {56},
number = {1},
pages = {239-244},
year = {2019},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.19.1.5159},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5159}
}

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