ABOUT INDEXING EDITORIAL BOARD ARCHIVES AUTHOR GUIDELINES SUBMIT PAPER NEWS, EVENTS AUTHOR'S PAGE CONTACT
Materiale Plastice
Cite as: Mater. Plast.
https://doi.org/10.37358/Mat.Plast.1964

OSIM Nr. R102356
ISSN Print 0025-5289
ISSN Online 2668-8220
Materiale Plastice - Latest Issue

Latest Issue >>>
ARCHIVES
   Volume 60, 2023
   Volume 59, 2022
   Volume 58, 2021
   Volume 57, 2020
   Volume 56, 2019
   Volume 55, 2018
   Volume 54, 2017
   Volume 53, 2016
   Volume 52, 2015
   Volume 51, 2014
   Volume 50, 2013
   Volume 49, 2012
   Volume 48, 2011
   Volume 47, 2010
   Volume 46, 2009
   Volume 45, 2008
   Volume 44, 2007
   Volume 43, 2006
   Volume 42, 2005
   Volume 41, 2004
   Volume 40, 2003
 
<<<< back

Materiale Plastice (Mater. Plast.), Year 2018, Volume 55, Issue 4, 691-695

https://doi.org/10.37358/MP.18.4.5102

Tudor Sorin Pop, Anca Maria Pop, Alina Dia Trambitas Miron, Klara Brinzaniuc, Simona Gurzu, Cristian Trambitas

In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study


Abstract:
The use of collagen scaffolds and stem cells for obtaining a tissue-engineering complex has been an important concept in promoting repair and regeneration of the bone tissue. Such units represent important steps in the development of an ideal scaffold-cell complex that would sustain new bone apposition. The aim of our study was to perform a histologic evaluation of the healing of critical-sized bone defects, using a biologic collagen scaffold with adipose-derived mesenchymal stem cells, in comparison to negative controls created in the adjacent bone. We used 16 Wistar rats and according to the study design 2 calvarial bone defects were created in each animal, one was filled with collagen seeded with adipose-derived stem cells and the other one was considered negative control. During the following month, at weekly intervals, the animals were euthanized and the specimens from bone defects were histologically evaluated. The results showed that these scaffolds were highly biocompatible as only moderate inflammation no rejection reactions were observed. Furthermore, the first signs of osseous healing appeared after two weeks accompanied by angiogenesis. Collagen scaffolds seeded with adipose-derived mesenchymal stem cells can be considered a promising treatment option in bone regeneration of large defects.


Keywords:
collagen scaffold; mesenchymal stem cells; osteogenic differentiation; bone regeneration

Issue: 2018 Volume 55, Issue 4
Pages: 691-695
Publication date: 2018/12/30
https://doi.org/10.37358/MP.18.4.5102
download pdf   Download Pdf Article
Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
POP, T.S., POP, A.M., MIRON, A.D.T., BRINZANIUC, K., GURZU, S., TRAMBITAS, C., In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study, Mater. Plast., 55(4), 2018, 691-695. https://doi.org/10.37358/MP.18.4.5102

Vancouver
Pop TS, Pop AM, Miron ADT, Brinzaniuc K, Gurzu S, Trambitas C. In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study. Mater. Plast.[internet]. 2018 Dec;55(4):691-695. Available from: https://doi.org/10.37358/MP.18.4.5102


APA 6th edition
Pop, T.S., Pop, A.M., Miron, A.D.T., Brinzaniuc, K., Gurzu, S. & Trambitas, C. (2018). In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study. Materiale Plastice, 55(4), 691-695. https://doi.org/10.37358/MP.18.4.5102


Harvard
Pop, T.S., Pop, A.M., Miron, A.D.T., Brinzaniuc, K., Gurzu, S., Trambitas, C. (2018). 'In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study', Materiale Plastice, 55(4), pp. 691-695. https://doi.org/10.37358/MP.18.4.5102


IEEE
T.S. Pop, A.M. Pop, A.D.T. Miron, K. Brinzaniuc, S. Gurzu, C. Trambitas, "In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study". Materiale Plastice, vol. 55, no. 4, pp. 691-695, 2018. [online]. https://doi.org/10.37358/MP.18.4.5102


Text
Tudor Sorin Pop, Anca Maria Pop, Alina Dia Trambitas Miron, Klara Brinzaniuc, Simona Gurzu, Cristian Trambitas,
In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study,
Materiale Plastice,
Volume 55, Issue 4,
2018,
Pages 691-695,
ISSN 2668-8220,
https://doi.org/10.37358/MP.18.4.5102.
(https://revmaterialeplastice.ro/Articles.asp?ID=5102)
Keywords: collagen scaffold; mesenchymal stem cells; osteogenic differentiation; bone regeneration


RIS
TY - JOUR
T1 - In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study
A1 - Pop, Tudor Sorin
A2 - Pop, Anca Maria
A3 - Miron, Alina Dia Trambitas
A4 - Brinzaniuc, Klara
A5 - Gurzu, Simona
A6 - Trambitas, Cristian
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2018
VL - 55
IS - 4
SP - 691
EP - 695
UR - https://doi.org/10.37358/MP.18.4.5102
KW - collagen scaffold
KW - mesenchymal stem cells
KW - osteogenic differentiation
KW - bone regeneration
ER -


BibTex
@article{MatPlast2018P691,
author = {Pop Tudor Sorin and Pop Anca Maria and Miron Alina Dia Trambitas and Brinzaniuc Klara and Gurzu Simona and Trambitas Cristian},
title = {In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study},
journal = {Materiale Plastice},
volume = {55},
number = {4},
pages = {691-695},
year = {2018},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.18.4.5102},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5102}
}


Downloads number: 0
<<<< back
 
  Search Authors
Crossref Member Badge
 DOI  logo
 Gold Open Access | Source=http://www.plos.org/  | Author=art designer at PLoS
Creative Commons License