In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study

Pop, Tudor Sorin; Pop, Anca Maria; Miron, Alina Dia Trambitas; Brinzaniuc, Klara; Gurzu, Simona; Trambitas, Cristian

Tudor Sorin Pop, Anca Maria Pop, Alina Dia Trambitas Miron, Klara Brinzaniuc, Simona Gurzu, Cristian Trambitas

In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study

Abstract:
The use of collagen scaffolds and stem cells for obtaining a tissue-engineering complex has been an important concept in promoting repair and regeneration of the bone tissue. Such units represent important steps in the development of an ideal scaffold-cell complex that would sustain new bone apposition. The aim of our study was to perform a histologic evaluation of the healing of critical-sized bone defects, using a biologic collagen scaffold with adipose-derived mesenchymal stem cells, in comparison to negative controls created in the adjacent bone. We used 16 Wistar rats and according to the study design 2 calvarial bone defects were created in each animal, one was filled with collagen seeded with adipose-derived stem cells and the other one was considered negative control. During the following month, at weekly intervals, the animals were euthanized and the specimens from bone defects were histologically evaluated. The results showed that these scaffolds were highly biocompatible as only moderate inflammation no rejection reactions were observed. Furthermore, the first signs of osseous healing appeared after two weeks accompanied by angiogenesis. Collagen scaffolds seeded with adipose-derived mesenchymal stem cells can be considered a promising treatment option in bone regeneration of large defects.

Keywords:
collagen scaffold; mesenchymal stem cells; osteogenic differentiation; bone regeneration

Issue: 2018 Volume 55, Issue 4

Pages: 691-695

Publication date: 2018/12/30

https://doi.org/10.37358/MP.18.4.5102

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
POP, T.S., POP, A.M., MIRON, A.D.T., BRINZANIUC, K., GURZU, S., TRAMBITAS, C., In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study, Mater. Plast., 55(4), 2018, 691-695. https://doi.org/10.37358/MP.18.4.5102

Vancouver
Pop TS, Pop AM, Miron ADT, Brinzaniuc K, Gurzu S, Trambitas C. In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study. Mater. Plast.[internet]. 2018 Dec;55(4):691-695. Available from: https://doi.org/10.37358/MP.18.4.5102

APA 6th edition
Pop, T.S., Pop, A.M., Miron, A.D.T., Brinzaniuc, K., Gurzu, S. & Trambitas, C. (2018). In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study. Materiale Plastice, 55(4), 691-695. https://doi.org/10.37358/MP.18.4.5102

Harvard
Pop, T.S., Pop, A.M., Miron, A.D.T., Brinzaniuc, K., Gurzu, S., Trambitas, C. (2018). 'In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study', Materiale Plastice, 55(4), pp. 691-695. https://doi.org/10.37358/MP.18.4.5102

IEEE
T.S. Pop, A.M. Pop, A.D.T. Miron, K. Brinzaniuc, S. Gurzu, C. Trambitas, "In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study". Materiale Plastice, vol. 55, no. 4, pp. 691-695, 2018. [online]. https://doi.org/10.37358/MP.18.4.5102

Text
Tudor Sorin Pop, Anca Maria Pop, Alina Dia Trambitas Miron, Klara Brinzaniuc, Simona Gurzu, Cristian Trambitas,
In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study,
Materiale Plastice,
Volume 55, Issue 4,
2018,
Pages 691-695,
ISSN 2668-8220,
https://doi.org/10.37358/MP.18.4.5102.
(https://revmaterialeplastice.ro/Articles.asp?ID=5102)
Keywords: collagen scaffold; mesenchymal stem cells; osteogenic differentiation; bone regeneration

RIS
TY - JOUR
T1 - In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study
A1 - Pop, Tudor Sorin
A2 - Pop, Anca Maria
A3 - Miron, Alina Dia Trambitas
A4 - Brinzaniuc, Klara
A5 - Gurzu, Simona
A6 - Trambitas, Cristian
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2018
VL - 55
IS - 4
SP - 691
EP - 695
UR - https://doi.org/10.37358/MP.18.4.5102
KW - collagen scaffold
KW - mesenchymal stem cells
KW - osteogenic differentiation
KW - bone regeneration
ER -

BibTex
@article{MatPlast2018P691,
author = {Pop Tudor Sorin and Pop Anca Maria and Miron Alina Dia Trambitas and Brinzaniuc Klara and Gurzu Simona and Trambitas Cristian},
title = {In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study},
journal = {Materiale Plastice},
volume = {55},
number = {4},
pages = {691-695},
year = {2018},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.18.4.5102},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=5102}
}

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