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Materiale Plastice
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https://doi.org/10.37358/Mat.Plast.1964

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ISSN Print 0025-5289
ISSN Online 2668-8220
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Materiale Plastice (Mater. Plast.), Year 2017, Volume 54, Issue 3, 581-585

https://doi.org/10.37358/MP.17.3.4901

Lacramioara Ochiuz, Cristina Ghiciuc, Maria Ignat, Marcel Popa, Catalina Anisoara Peptu, Aurelia Vasile

Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite


Abstract:
Developing biomaterials with optimal loading properties and controlled release of drugs is a priority of medical research. Clinoptilolite is a natural zeolite used in various industrial processes. Its texture and structure recommend its use as a biocompatible matrix for the development of modified release drug delivery systems. The present study aims to develop and characterize modified-release systems based on bexarotene loaded clinoptilolite. Bexarotene is a retinoid that is used as an anticancer agent in the topical treatment of cutaneous T-cell lymphoma. By adding bexarotene to these systems, skin delivered antineoplastic therapy with bexarotene can be improved. Clinoptilolite was obtained by purifying the volcanic tuffs from Mirsid quarry, Salaj Romania. After thermal and chemical purification, two monoionic forms of clinoptilolite were obtained. They were labeled as Na-CLI and H-CLI, respectively. Their texture and structure were characterized by specific methods. Subsequently, these forms of clinoptilolite were used as hosts for bexarotene loading by wet impregnation. The obtained results showed that the two modified-release systems Bxt@Na and Bxt@H, respectively, have no incompatibilities and provide prolonged release of the drug.


Keywords:
clinoptilolite; bexarotene; modified-release drug delivery system

Issue: 2017 Volume 54, Issue 3
Pages: 581-585
Publication date: 2017/9/30
https://doi.org/10.37358/MP.17.3.4901
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Creative Commons License
This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
OCHIUZ, L., GHICIUC, C., IGNAT, M., POPA, M., PEPTU, C.A., VASILE, A., Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite, Mater. Plast., 54(3), 2017, 581-585.

Vancouver
Ochiuz L, Ghiciuc C, Ignat M, Popa M, Peptu CA, Vasile A. Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite. Mater. Plast.[internet]. 2017 Jul;54(3):581-585. Available from: https://doi.org/10.37358/MP.17.3.4901


APA 6th edition
Ochiuz, L., Ghiciuc, C., Ignat, M., Popa, M., Peptu, C.A. & Vasile, A. (2017). Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite. Materiale Plastice, 54(3), 581-585. https://doi.org/10.37358/MP.17.3.4901


Harvard
Ochiuz, L., Ghiciuc, C., Ignat, M., Popa, M., Peptu, C.A., Vasile, A. (2017). 'Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite', Materiale Plastice, 54(3), pp. 581-585. https://doi.org/10.37358/MP.17.3.4901


IEEE
L. Ochiuz, C. Ghiciuc, M. Ignat, M. Popa, C.A. Peptu, A. Vasile, "Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite". Materiale Plastice, vol. 54, no. 3, pp. 581-585, 2017. [online]. https://doi.org/10.37358/MP.17.3.4901


Text
Lacramioara Ochiuz, Cristina Ghiciuc, Maria Ignat, Marcel Popa, Catalina Anisoara Peptu, Aurelia Vasile,
Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite,
Materiale Plastice,
Volume 54, Issue 3,
2017,
Pages 581-585,
ISSN 2668-8220,
https://doi.org/10.37358/MP.17.3.4901.
(https://revmaterialeplastice.ro/Articlegs.asp?ID=4901)
Keywords: clinoptilolite; bexarotene; modified-release drug delivery system


RIS
TY - JOUR
T1 - Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite
A1 - Ochiuz, Lacramioara
A2 - Ghiciuc, Cristina
A3 - Ignat, Maria
A4 - Popa, Marcel
A5 - Peptu, Catalina Anisoara
A6 - Vasile, Aurelia
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2017
VL - 54
IS - 3
SP - 581
EP - 585
UR - https://doi.org/10.37358/MP.17.3.4901
KW - clinoptilolite
KW - bexarotene
KW - modified-release drug delivery system
ER -


BibTex
@article{MatPlast2017P581,
author = {Ochiuz Lacramioara and Ghiciuc Cristina and Ignat Maria and Popa Marcel and Peptu Catalina Anisoara and Vasile Aurelia},
title = {Development of a Modified - release Drug Delivery System with Bexarotene Loaded in Clinoptilolite},
journal = {Materiale Plastice},
volume = {54},
number = {3},
pages = {581-585},
year = {2017},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.17.3.4901},
url = {https://revmaterialeplastice.ro/Articlegs.asp?ID=4901}
}
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