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Materiale Plastice
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Materiale Plastice (Mater. Plast.), Year 2017, Volume 54, Issue 1, 160-167

https://doi.org/10.37358/MP.17.1.4808

Toni Andor Cigu, Mihaela Nicoleta Holban, Anca Niculina Cadinoiu, Valeriu Sunel, Catalina Lionte, Marcel Popa, Jacques Desbrieres, Corina Cheptea

Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections


Abstract:
The aim of this research was the synthesis of novel 2,3-disubstituted 1,3 thiazolidines, derived from 5-nitroindazole with antimicrobial activity and their encapsulation into polymer nanocapsules. Starting from previously synthesised hydrazones, there have been obtained novel thiazolidines by reaction with thioglycolic acid. The envisaged chemical structures were confirmed by spectral and elemental analysis. Two of the obtained thiazolidines were encapsulated into cationic Eudragit E100 nanocapsules, obtained by nanoprecipitation. In order to enhance drug release characteristics and particle stability, Eudragit E100 nanocapsules were covered with anionic polysaccharide (sodium alginate), thus forming a complex polyelectrolyte based membrane. The obtained nanocapsules presented a slower and more controlled drug release. The synthesized active principles, in free state and encapsulated into polymer nanocapsules, were tested for their acute toxicity and their influence on the development of model bacterial strains (Staphylococcus mutans, Actinobacillus actinomycetemcomitans, Bacillus subtilis, Bacillus cereus, Salmonella enteritidis, Escherichia coli and Staphylococcus aureus).


Keywords:
polyelectrolyte; Eudragit E100; nanocapsules; sodium alginate; thiazolidine; antimicrobial

Issue: 2017 Volume 54, Issue 1
Pages: 160-167
Publication date: 30/03/2017
https://doi.org/10.37358/MP.17.1.4808
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This article is published under the Creative Commons Attribution 4.0 International License
Citation Styles
Cite this article as:
CIGU, T.A., HOLBAN, M.N., CADINOIU, A.N., SUNEL, V., LIONTE, C., POPA, M., DESBRIERES, J., CHEPTEA, C., Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections, Mater. Plast., 54(1), 2017, 160-167.

Vancouver
Cigu TA, Holban MN, Cadinoiu AN, Sunel V, Lionte C, Popa M, Desbrieres J, Cheptea C. Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections. Mater. Plast.[internet]. 2017 Jan;54(1):160-167. Available from: https://doi.org/10.37358/MP.17.1.4808


APA 6th edition
Cigu, T.A., Holban, M.N., Cadinoiu, A.N., Sunel, V., Lionte, C., Popa, M., Desbrieres, J. & Cheptea, C. (2017). Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections. Materiale Plastice, 54(1), 160-167. https://doi.org/10.37358/MP.17.1.4808


Harvard
Cigu, T.A., Holban, M.N., Cadinoiu, A.N., Sunel, V., Lionte, C., Popa, M., Desbrieres, J., Cheptea, C. (2017). 'Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections', Materiale Plastice, 54(1), pp. 160-167. https://doi.org/10.37358/MP.17.1.4808


IEEE
T.A. Cigu, M.N. Holban, A.N. Cadinoiu, V. Sunel, C. Lionte, M. Popa, J. Desbrieres, C. Cheptea, "Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections". Materiale Plastice, vol. 54, no. 1, pp. 160-167, 2017. [online]. https://doi.org/10.37358/MP.17.1.4808


Text
Toni Andor Cigu, Mihaela Nicoleta Holban, Anca Niculina Cadinoiu, Valeriu Sunel, Catalina Lionte, Marcel Popa, Jacques Desbrieres, Corina Cheptea,
Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections,
Materiale Plastice,
Volume 54, Issue 1,
2017,
Pages 160-167,
ISSN 2668-8220,
https://doi.org/10.37358/MP.17.1.4808.
(https://revmaterialeplastice.ro/Articles.asp?ID=4808)
Keywords: polyelectrolyte; Eudragit E100; nanocapsules; sodium alginate; thiazolidine; antimicrobial


RIS
TY - JOUR
T1 - Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections
A1 - Cigu, Toni Andor
A2 - Holban, Mihaela Nicoleta
A3 - Cadinoiu, Anca Niculina
A4 - Sunel, Valeriu
A5 - Lionte, Catalina
A6 - Popa, Marcel
A7 - Desbrieres, Jacques
A8 - Cheptea, Corina
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2017
VL - 54
IS - 1
SP - 160
EP - 167
UR - https://doi.org/10.37358/MP.17.1.4808
KW - polyelectrolyte
KW - Eudragit E100
KW - nanocapsules
KW - sodium alginate
KW - thiazolidine
KW - antimicrobial
ER -


BibTex
@article{MatPlast2017P160,
author = {Cigu Toni Andor and Holban Mihaela Nicoleta and Cadinoiu Anca Niculina and Sunel Valeriu and Lionte Catalina and Popa Marcel and Desbrieres Jacques and Cheptea Corina},
title = {Polyelectrolyte Complex Based Nanocapsules Carrying Novel 5-Nitroindazole Thiazolidines with Potential Use in Treating Oral Infections},
journal = {Materiale Plastice},
volume = {54},
number = {1},
pages = {160-167},
year = {2017},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.17.1.4808},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=4808}
}

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