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Materiale Plastice
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https://doi.org/10.37358/Mat.Plast.1964

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Materiale Plastice (Mater. Plast.), Year 2016, Volume 53, Issue 3, 419-423



Adi Ghebaur, Brindusa Balanuca, Sorina Alexandra Garea, Horia Iovu

pH -Sensitive Clays as Drug Delivery Carriers for Controlled Release of Hydrocortisone


Abstract:
The main goal of this study was to modify halloysite with polyethylene glycol methacrylate and polyethylene glycol dimethacrylate in order to realize some pH sensitive controlled drug delivery systems. The obtained samples were characterized by spectral techniques (FTIR, XPS) and thermal techniques (TGA, DSC). There was also studied the influence of clay type and initial clay amount onto the drug adsorption process within halloysite. The hydrocortisone release profile was also investigated in simulated gastric fluid and simulated intestinal fluid.


Keywords:
halloysite; modification; drug encapsulation; methacrylate groups; hydrocortisone

Issue: 2016 Volume 53, Issue 3
Pages: 419-423
Publication date: 2016/9/30
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