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Materiale Plastice
Cite as: Mater. Plast.
https://doi.org/10.37358/Mat.Plast.1964

OSIM Nr. R102356
ISSN Print 0025-5289
ISSN Online 2668-8220
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Materiale Plastice (Mater. Plast.), Year 2014, Volume 51, Issue 2,





Ana Maria BARGAN, Gabriela CIOBANU, Constantin LUCA, Mariana DIACONU, Ioan Gabriel SANDU Cellulose Acetate / Hydroxyapatite / Nystatin Biocomposites with Antifugal Activity


Abstract:
The aim of our study was to obtain cellulose acetate composites based on hydroxyapatite and nystatin with increased local therapeutic effect in the therapy of candidiasis. The porous composites were obtained by phase inversion method. Antifungal susceptibility of the samples was investigated by the Kirby Bauer Disk Diffusion test. The method has demonstrated an antifungal effect of the samples against Candida albicans as well as the fact that the polyene antibiotic nystatin might be an optimal choice as active agent incorporated in a composite. Also we have studied the swelling and the degradation of the membranes. These measurements help us better understand the water and PBS absorption capacity of the polymer matrix. Keywords: Composite, cellulose acetate, hydroxyapatite, nystatin, antifungal activity



Issue: 2014 Volume 51, Issue 2
Pages:
Publication date: 2014/6/30
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