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Materiale Plastice
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Materiale Plastice (Mater. Plast.), Year 2009, Volume 46, Issue 3,





MANUELA FLOREA-SPIROIU, MIHAELA OLTEANU, VIORICA STĂNESCU, SANDU PERETZ Biopolymeric Microcapsules for Controlled Release of Pralidoxime Chloride


Abstract:
Pralidoxime chloride (PAM) was encapsulated in biopolymeric membranes in order to evaluate the kinetics of release in aqueous solution. PAM is an efficient cholinesterase reactivator with a pronounced hydrophilic character. The biopolymeric membranes were prepared by crosslinking, directly in aqueous solution and the monodisperse spherical microcapsules made by this method had diameters between 1 and 3 mm. PAM was embedded “in situ” in microcapsules prepared from natural polymers as sodium alginate, chitosan and gelatin. The release data were fitted by first order kinetic equation, Weibull, Peppas and Higuchi semiempirical equations to obtain the kinetic parameters of controlled PAM release. The embedding of PAM in biopolymeric membranes was achieved in order to prepare a sustained release pharmaceutical formulation for oral administration. Keywords: biopolymeric microcapsules, Pralidoxime chloride, drug release



Issue: 2009 Volume 46, Issue 3
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