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Materiale Plastice
Cite as: Mater. Plast.
https://doi.org/10.37358/Mat.Plast.1964

OSIM Nr. R102356
ISSN Print 0025-5289
ISSN Online 2668-8220
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Materiale Plastice (Mater. Plast.), Year 2007, Volume 44, Issue 3,





In-vitro Studies Concerning the Release of Nystatin from a Polyurethane Urea Microporous Membrane


Abstract:
The studies were concerned on the releasing of nystatin from polyurethane urea (PUU) microporous membrane at different pH values at room temperature. The whole ATR-FTIR spectrum of PUU-nystatin is shifted to smaller wave numbers compared to control PUU which indicates the increasing of structurated degree of PUU-nystatin. The stress-strain curves are sustained by the ATR-FTIR results demonstrating the structurating effects of a polar bioactive nystatin materialized through an increasing of the initial modulus. The nystatin delivery in watery solution has a strong reaction to pH. At pH 3, in the first 170 minutes, the nystatin is released in proportion of 38% whereafter drug release is approximately constant in time. Key words: polyurethane urea, nystatin, release



Issue: 2007 Volume 44, Issue 3
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