LETITIA DOINA DUCEAC, GETA MITREA, ELENA ARIELA BANU, MADALINA IRINA CIUHODARU, IRINA MIHAELA CIOMAGA, DANIELA LUMINITA ICHIM2,8, MARCU CONSTANTIN, ALINA COSTINA LUCA SYNTHESIS AND CHARACTERIZATION OF CARBAPENEM BASED NANOHYBRIDS AS ANTIMICROBIAL AGENTS FOR MULTIDRUG RESISTANT BACTERIA
Carbapenem antibiotics resistance is a medical threat in antibacterial therapy as the pathogen resistant strains easily evolve a multi-drug resistance action to other incurable agents. The protective transport of current antibiotic molecules using nano-carriers initiates a huge approach in the antibacterial therapy, allowing the nanohybrids to defeat all these health threat pathogen agents. Chitosan is a linear cationic polysaccharide being often used in medical area as a biocompatible encapsulating agent in antibiotic delivery nanosystems. This work refers to encapsulation of imipenem into biodegradable chitosan nanoparticles in order to destroy antibiotic-resistant bacteria and limit the microbial adhesion and multiplication. Nanoparticles were prepared by ion gelation method using tripolyphosphate as cross linking agent. The obtained hybrid nanocapsules were then characterized and evaluated as a potential nano-device to beat antimicrobial resistance.