MONICA ILIUTA STAMATE, CIPRIAN STAMATE, DANIEL TIMOFTE, BOGDAN CIUNTU, CARMEN GAFITANU, ALINA STEFANACHE, LACRAMIOARA OCHIUZ EFFECT OF POLYMERS ON THE PHARMACO-MECHANICAL PROPERTIES OF DIRECT COMPRESSED TABLETS WITH KETOPROFEN In this study, the effect of polymers on the mechanical properties of ketoprofen extended drug release systems were studied. Many polymers are added in formulation of compressed tablets in order to improve the physicochemical characteristics of the drug release system. The samples were made in the form of cylindrical tablet about 9 mm in diameter, containing different mixtures of drug substances and excipients acording to seven formulations. Cylindrical tablets containing mixtures of ketoprofen and various types of polymers are made by direct compression method. Among the binders used were a series of different polymers like Kollidon va 64, hydroxypropyl methyl cellulose and sodium carboxyl methyl cellulose. Mechanical parameters such as hardness, mechanical strenght, friability and roughness were studied in order to determine how they are influenced by polymeric binders.