LETITIA DOINA DUCEAC, ALINA COSTINA LUCA, GETA MITREA, ELENA ARIELA BANU, MADALINA IRINA CIUHODARU, IRINA CIOMAGA, DANIELA LUMINITA ICHIM, GINEL BACI CEFTRIAXONE INTERCALATED NANOSTRUCTURES USED TO IMPROVE MEDICAL TREATMENT The development of antibiotic resistance in bacteria possesses a huge threat to public health by nullifying the effect of even the most efficient antibiotics. From years, LDHs type nanomaterials have been used as drug carriers for a wide variety of pharmaceutically active molecules due to their delivery properties, making these inorganic-organic nanohybrids very efficient antimicrobial agents. The major purpose of this work was to synthesize and characterize ceftriaxone intercalated layered nanostructures for further use to treat some infections, mostly of them child infections. The novel nanohybrid materials were prepared by ion exchange route and coprecipitation method. Structural and morphological characterization was performed by FTIR, EDX and SEM techniques. The results revealed a high incorporation of the drug in the interlayer space of promising nanostructures.
Keywords: nanostructures, ceftriaxone, SEM, antimicrobial agents, medical treatment