ALINA COSTINA LUCA, LETITIA DOINA DUCEAC, GETA MITREA, MADALINA IRINA CIUHODARU, DANIELA LUMINITA ICHIM, GINEL BACIU, ELENA ARIELA BANU, ALIN CONSTANTIN IORDACHE ANTIBIOTIC ENCAPSULATED NANOMATERIALS WITH APPLICATION IN MEDICAL AREA Novel materials belonging to the class of anionic clays are synthesized by investigating their properties at nano scale. Thus, hydrotalcites or layered double hydroxides (LDHs) were used as drug delivery carriers in order to prevent or to treat infections produced by some pathogen agents. Their physical and chemical properties allow them to include different molecules in the interlayer space and then to ensure their transport to the target. The current work reveals the obtaining of nanohybrid compounds type amoxicillin/clavulanic acid-layered double hydroxides (Amox/CA-LDHs) followed by structural and morphological characterization of these nanostructures for future applications as drug controlled release systems. IR spectroscopy and Scanning Electron Microscopy pointed out LDHs ability to incorporate the medicines without modification of therapeutic activity.
Keywords: antibiotic, layered double hydroxides (LDHs), drug delivery, IR spectroscopy, medical area