CATALINA RADULESCU, DANIELA MIRICESCU, BOGDAN CALENIC, RADU RADULESCU, IULIA STANESCU, ANCA CALENIC, ALEXANDRA TOTAN, BOGDANA VIRGOLICI, DANIELA BALAN, MARIA GREABU THE ANTIOXIDANT EFFECT OF PLGA NANOPARTICLES ENCAPSULATED WITH LUTEIN IN RATS TREATED WITH HYPERCALORIC DIET Poly lactic-co-glycolic acid (PLGA) is a biodegradable polymer that has been the focus of intense research due to its potential applications in medical research. Its uses in nanotechnology are underlined by its capability of targeting various cells and delivering active compounds to different human tissues. To date, PLGA nanoparticles are employed in areas such as vaccination therapy, diagnostic imaging procedure and various applications in various anticancer therapies. The aim of the present study is to measure and evaluate different correlations between oxidative stress parameters in spleen and liver following administration of nanoparticles encapsulated with lutein in an animal model. Our results show that acute oral administration of PLGA NPs induces a change in the oxidative stress status in both liver and spleen of rats, but does not induce oxidative stress damage to cell structures such as lipids or proteins.
Keywords: polymeric nanoparticles, oxidative stress, liver, spleen, animal study