FAWZIA SHA’AT, RAMONA DANIELA PAVALOIU, DANIELA CRINA SALCEANU, CRISTINA HLEVCA, GHEORGHE NECHIFOR FORMULATION OF POLYMERIC MULTICOMPONENT SYSTEMS CONTAINING CARDIOVASCULAR APIS The main aim of this study was to prepare and characterize polymeric nanoparticles containing two cardiovascular active pharmaceutical ingredients: valsartan (VAL) and amlodipine besylate (AML). Six formulations were evaluated with different ratios of AML:VAL:PLGA (1:16:17, 1:16:34, and 1:16:51) and different stirring speed (1200 and 2400 rpm). Encapsulation efficiency (EE, %) and particle size analyses were performed to characterize and optimize the formulation. All loaded nanoparticles showed a high EE (%), nano-size, negative x-potential and a high homogeneity.
Keywords: nanotechnology, cardiovascular drugs, drug delivery systems, medicinal chemistry