RAZVAN SUSAN, RAMONA PANA, IOANA TUTA SAS, FLORIN BORCAN, ELENA ARDELEAN, ALEXANDRA ENACHE, IULIA PINZARU BIOPHYSICAL ASSESSMENT AND IMPACT OF CATALYST ON THE PROPERTIES OF POLYURETHANE DRUG CARRIERS The metal complexes and amine compounds are the most frequent categories of catalysts used in polyurethanes synthesis. Unfortunately, all auxiliary substances added to a synthesis increase the toxicological risk of final products used in a therapy. In the present study, polyether-urethane (PU) microstructures with and without catalyst were obtained. These structures were characterized by the measurement of samplesí pH, of their size and stability, were obtained and the skin irritation potential. The results show that samples with a neutral pH, PU microstructures with sizes between 120 and 165 nm and with a medium stability. It was found that the microstructures from syntheses with catalyst present increased values of skin irritation.
Keywords: DABCO, drug delivery system, skin irritation, Zeta potential