Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model

Miricescu, Daniela; Stanescu, Iulia; Perlea, Paula; Calenic, Bogdan; Radulescu, Radu; Totan, Alexandra; Virgolici, Bogdana; Sabliov, Cristina; Grea, Maria

Daniela Miricescu, Iulia Stanescu, Paula Perlea, Bogdan Calenic, Radu Radulescu, Alexandra Totan, Bogdana Virgolici, Cristina Sabliov, Maria Grea

Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model

Abstract:
In the recent years, engineered nanoparticles (NPs) such as PLGA or poly-lactic-co-glycolic acid, have raised a substantial interest due to their possible medical applications in vaccination, diagnostic imaging procedures, cancer therapy or sustained delivery of drugs. The main aim of the present work is to evaluate key oxidative stress parameters in several organs following NPs administration in an animal model. Our data shows that acute oral administration of PLGA NPs induces a change in the antioxidant status in both rat liver and spleen, but may not induce oxidative stress damage to cell structures such as lipid or protein oxidation.

Keywords:
polymeric nanoparticles; oxidative stress; liver; spleen

Issue: 2017 Volume 54, Issue 2

Pages: 249-252

Publication date: 2017/6/30

https://doi.org/10.37358/MP.17.2.4826

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This article is published under the Creative Commons Attribution 4.0 International License

Citation Styles

Cite this article as:
MIRICESCU, D., STANESCU, I., PERLEA, P., CALENIC, B., RADULESCU, R., TOTAN, A., VIRGOLICI, B., SABLIOV, C., GREA, M., Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model, Mater. Plast., 54(2), 2017, 249-252. https://doi.org/10.37358/MP.17.2.4826

Vancouver
Miricescu D, Stanescu I, Perlea P, Calenic B, Radulescu R, Totan A, Virgolici B, Sabliov C, Grea M. Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model. Mater. Plast.[internet]. 2017 Apr;54(2):249-252. Available from: https://doi.org/10.37358/MP.17.2.4826

APA 6th edition
Miricescu, D., Stanescu, I., Perlea, P., Calenic, B., Radulescu, R., Totan, A.,... Grea, M. (2017). Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model. Materiale Plastice, 54(2), 249-252. https://doi.org/10.37358/MP.17.2.4826

Harvard
Miricescu, D., Stanescu, I., Perlea, P., Calenic, B., Radulescu, R., Totan, A., Virgolici, B., Sabliov, C., Grea, M. (2017). 'Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model', Materiale Plastice, 54(2), pp. 249-252. https://doi.org/10.37358/MP.17.2.4826

IEEE
D. Miricescu, I. Stanescu, P. Perlea, B. Calenic, R. Radulescu, A. Totan, B. Virgolici, C. Sabliov, M. Grea, "Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model". Materiale Plastice, vol. 54, no. 2, pp. 249-252, 2017. [online]. https://doi.org/10.37358/MP.17.2.4826

Text
Daniela Miricescu, Iulia Stanescu, Paula Perlea, Bogdan Calenic, Radu Radulescu, Alexandra Totan, Bogdana Virgolici, Cristina Sabliov, Maria Grea,
Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model,
Materiale Plastice,
Volume 54, Issue 2,
2017,
Pages 249-252,
ISSN 2668-8220,
https://doi.org/10.37358/MP.17.2.4826.
(https://revmaterialeplastice.ro/Articles.asp?ID=4826)
Keywords: polymeric nanoparticles; oxidative stress; liver; spleen

RIS
TY - JOUR
T1 - Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model
A1 - Miricescu, Daniela
A2 - Stanescu, Iulia
A3 - Perlea, Paula
A4 - Calenic, Bogdan
A5 - Radulescu, Radu
A6 - Totan, Alexandra
A7 - Virgolici, Bogdana
A8 - Sabliov, Cristina
A9 - Grea, Maria
JF - Materiale Plastice
JO - Mater. Plast.
PB - Materiale Plastice SRL
SN - 2668-8220
Y1 - 2017
VL - 54
IS - 2
SP - 249
EP - 252
UR - https://doi.org/10.37358/MP.17.2.4826
KW - polymeric nanoparticles
KW - oxidative stress
KW - liver
KW - spleen
ER -

BibTex
@article{MatPlast2017P249,
author = {Miricescu Daniela and Stanescu Iulia and Perlea Paula and Calenic Bogdan and Radulescu Radu and Totan Alexandra and Virgolici Bogdana and Sabliov Cristina and Grea Maria},
title = {Oxidative Stress Following PLGA Nanoparticles Administration to an Animal Model},
journal = {Materiale Plastice},
volume = {54},
number = {2},
pages = {249-252},
year = {2017},
issn = {2668-8220},
doi = {https://doi.org/10.37358/MP.17.2.4826},
url = {https://revmaterialeplastice.ro/Articles.asp?ID=4826}
}

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